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Peptide record

TPDB09310

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09310
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIGPGKFLHSAKKF
Physicochemical Analysis
C119H186N30O22
RNDCEQMTYV
K
2388.97
11.29
8
0
8
+7
1.65
-0.615
63.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
230.22
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
1
I
2
L
7
K
0
M
3
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 1 L: 2 K: 7 M: 0 F: 3 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
20
C119H186N30O22
2388.97
11.29
+7
1.65
-0.615
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Escherichia coli

Source & Reference

NA

Other

active against Gram- E. coli (MIC 3.12 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 0.78 uM), Gram+ B. subtilis (MIC 0.78 u
Evidence 2 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

S. typhimurium

Source & Reference

NA

Other

active against Gram- E. coli (MIC 3.12 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 0.78 uM), Gram+ B. subtilis (MIC 0.78 uM), S. pyogenes (MIC 0.78 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

active against Gram- E. coli (MIC 3.12 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 0.78 uM), Gram+ B. subtilis (MIC 0.78 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

B. subtilis

Source & Reference

NA

Other

- E. coli (MIC 3.12 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 0.78 uM), Gram+ B. subtilis (MIC 0.78 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). weak activity to cancer cells: J
Evidence 5 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Streptococcus pyogenes

Source & Reference

NA

Other

typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 0.78 uM), Gram+ B. subtilis (MIC 0.78 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). weak activity to cancer cells: Jurkat (IC50 75 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

aeruginosa (MIC 0.78 uM), Gram+ B. subtilis (MIC 0.78 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). weak activity to cancer cells: Jurkat (IC50 75 uM).
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells. | Biochim Biophys Acta | 2000
Evidence 8 Activity

Activity

IC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Hemolysis 0% (100 µM) | Cytotoxicity: NIH-3T3 fibroblast: IC50>100 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2000 Feb 15 1463(2):209-18.