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Peptide record

TPDB09306

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09306
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SWASMAKKLKEYMEKLKQRA
Physicochemical Analysis
C108H180N30O29S2
NDCGHIFPTV
K
2426.92
10.47
6
2
9
+4
5.76
-1.075
54.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
6990
288.02
4
Residue Composition
number
3
A
1
R
0
N
0
D
0
C
2
E
1
Q
0
G
0
H
0
I
2
L
5
K
2
M
0
F
0
P
2
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 5 M: 2 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
20
C108H180N30O29S2
2426.92
10.47
+4
5.76
-1.075
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
23-28 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 23-28 uM), P-aeruginosa (MIC>45 uM), Gram+ A. globiformis, B. subtilis (MIC 0.7-2.9 uM), yeasts P.
Evidence 2 Activity

Activity

MIC
Antibacterial
0.7-2.9 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

oli DH5alpha, E. coli DH1 (MIC 23-28 uM), P-aeruginosa (MIC>45 uM), Gram+ A. globiformis, B. subtilis (MIC 0.7-2.9 uM), yeasts P. pastoris, S. cerevisiae (MIC 23 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
23 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

nosa (MIC>45 uM), Gram+ A. globiformis, B. subtilis (MIC 0.7-2.9 uM), yeasts P. pastoris, S. cerevisiae (MIC 23 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
23-28 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 23-28 uM), P-aeruginosa (MIC>45 uM), Gram+ A. globiformis, B. subtilis (MIC 0.7-2.9 uM), yeasts P.
Evidence 5 Activity

Activity

MIC
Antifungal
0.7-2.9 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

oli DH5alpha, E. coli DH1 (MIC 23-28 uM), P-aeruginosa (MIC>45 uM), Gram+ A. globiformis, B. subtilis (MIC 0.7-2.9 uM), yeasts P. pastoris, S. cerevisiae (MIC 23 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
23 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nosa (MIC>45 uM), Gram+ A. globiformis, B. subtilis (MIC 0.7-2.9 uM), yeasts P. pastoris, S. cerevisiae (MIC 23 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
23-28 µM

Target

Escherichia coli DH1

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 23-28 uM), P-aeruginosa (MIC>45 uM), Gram+ A. globiformis, B. subtilis (MIC 0.7-2.9 uM), yeasts P.
Evidence 8 Activity

Activity

MIC
Antiparasitic
0.7-2.9 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

oli DH5alpha, E. coli DH1 (MIC 23-28 uM), P-aeruginosa (MIC>45 uM), Gram+ A. globiformis, B. subtilis (MIC 0.7-2.9 uM), yeasts P. pastoris, S. cerevisiae (MIC 23 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
23 µM

Target

S. cerevisiae

Source & Reference

DRAMP

Other

nosa (MIC>45 uM), Gram+ A. globiformis, B. subtilis (MIC 0.7-2.9 uM), yeasts P. pastoris, S. cerevisiae (MIC 23 uM).
Evidence 10 Activity

Activity

20% Hemolysis
Toxicity
>120 µM
Hemolytic Cytotoxic
20% Hemolysis | >120 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. | J Biol Chem | 2006
Evidence 11 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.16735513]20% hemolytic activity at >120 µM against rabbit erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2006 Jul 28 281(30):20983-209892.