TPDB09305

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli ML-35 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureu

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-8 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli ML-35 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. m

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli ML-35 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active ag

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5-4 µM

Target

Target Organism Staphylococcus aureus 710A or MRSA

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulan

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism B. megaterium BM11

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus simulans 22

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM),

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

um BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 u

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus haemolyticus I-10925

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

t strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Citrobacter freundii I-11090

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

terococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451 (MIC 2 uM), and C. albicans (MIC

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Klebsiella pneumoniae I-10910

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

emolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451 (MIC 2 uM), and C. albicans (MIC 4 uM or greater),

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism S. maltophila O-16451

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451 (MIC 2 uM), and C. albicans (MIC 4 uM or greater),

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli ML-35 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureu

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4-8 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli ML-35 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. m

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli ML-35 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active ag

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.5-4 µM

Target

Target Organism Staphylococcus aureus 710A or MRSA

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

IC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulan

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism B. megaterium BM11

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Staphylococcus simulans 22

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM),

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.5 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

um BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 u

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Staphylococcus haemolyticus I-10925

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

t strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Citrobacter freundii I-11090

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

terococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451 (MIC 2 uM), and C. albicans (MIC

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Klebsiella pneumoniae I-10910

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

emolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451 (MIC 2 uM), and C. albicans (MIC 4 uM or greater),

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism S. maltophila O-16451

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451 (MIC 2 uM), and C. albicans (MIC 4 uM or greater),

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against E. coli ML-35 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureu

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4-8 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli ML-35 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. m

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli ML-35 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active ag

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.5-4 µM

Target

Target Organism Staphylococcus aureus 710A or MRSA

Source & Reference

Database Source DRAMP

Other

Evidence Text

IC 2 uM), P. aeruginosa ATCC 27853 (MIC 4-8 uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulan

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism B. megaterium BM11

Source & Reference

Database Source DRAMP

Other

Evidence Text

uM), S. typhimurium ATCC 14028 (MIC 8 ug/ml), S. aureus 710A or MRSA (MIC 1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Staphylococcus simulans 22

Source & Reference

Database Source DRAMP

Other

Evidence Text

1.5-4 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM),

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.5 µM

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Evidence Text

um BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 u

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Staphylococcus haemolyticus I-10925

Source & Reference

Database Source DRAMP

Other

Evidence Text

t strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

M. luteus (MIC 0.5 uM), Enterococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Citrobacter freundii I-11090

Source & Reference

Database Source DRAMP

Other

Evidence Text

terococcus spp (MIC 2 uM), S. haemolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451 (MIC 2 uM), and C. albicans (MIC

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Klebsiella pneumoniae I-10910

Source & Reference

Database Source DRAMP

Other

Evidence Text

emolyticus I-10925 (MIC 2 uM), S. epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451 (MIC 2 uM), and C. albicans (MIC 4 uM or greater),

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism S. maltophila O-16451

Source & Reference

Database Source DRAMP

Other

Evidence Text

epidermidis (MIC 2 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 2 uM), S. maltophila O-16451 (MIC 2 uM), and C. albicans (MIC 4 uM or greater),

Evidence 37 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. | Arch Biochem Biophys | 2005

Evidence 38 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. | Arch Biochem Biophys | 2005

Evidence 39 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 %

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.15639237]20% hemolysis at 10µM, 100% hemolysis at 100µM against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Arch Biochem Biophys. 2005 Feb 15 434(2):358-64.

Evidence 40 Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Database Source PD_Hemolysis