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Peptide record

TPDB09303

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09303
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
C109H190N36O29
ACGHMWY
R
2468.93
11.96
6
2
7
+4
7.46
-0.755
107.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
0
A
4
R
1
N
1
D
0
C
1
E
1
Q
0
G
0
H
2
I
2
L
2
K
0
M
1
F
1
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
20
C109H190N36O29
2468.93
11.96
+4
7.46
-0.755
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus mprF (KO) (diffusion assays), C. albicans. It also reduced the viability of T. vaginalis on a 5-nitroimidazole-sensitive and a 5-nitroimidazole-resistant strain ( Ramírez-Ledesma et al., 2022 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus mprF (KO) (diffusion assays), C. albicans. It also reduced the viability of T. vaginalis on a 5-nitroimidazole-sensitive and a 5-nitroimidazole-resistant strain ( Ramírez-Ledesma et al., 2022 ).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against S. aureus mprF (KO) (diffusion assays), C. albicans. It also reduced the viability of T. vaginalis on a 5-nitroimidazole-sensitive and a 5-nitroimidazole-resistant strain ( Ramírez-Ledesma et al., 2022 ).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against S. aureus mprF (KO) (diffusion assays), C. albicans. It also reduced the viability of T. vaginalis on a 5-nitroimidazole-sensitive and a 5-nitroimidazole-resistant strain ( Ramírez-Ledesma et al., 2022 ).
Evidence 5 Activity

Activity

50% cell death
Toxicity
>40.5 µM
Cytotoxic
50% cell death | >40.5 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins | Antimicrob Agents Chemother | 2008
Evidence 6 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. | J Immunol | 2004