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Peptide record

TPDB09269

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09269
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 20-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RYRRKKKMKKALQYIKLLKE
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C120H213N37O26S1
NDCGHFPSTWV
K
2622.30
11.25
10
1
8
+9
3.62
-1.540
83.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
2980
1.14
3
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
1
I
3
L
7
K
1
M
0
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 3 K: 7 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
20 reviewed residue count
C120H213N37O26S1 sequence-only estimate (linear, free termini)
2622.30 sequence-only estimate (linear, free termini)
11.25 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
3.62 sequence-only estimate (linear, free termini)
-1.540 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

14% Hemolysis
Toxicity
350 µM
Hemolytic Cytotoxic
14% Hemolysis | 350 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A New Synthetic Peptide Having Two Target of Antibacterial Action in E. coli ML35. | Front Microbiol | 2016
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
1.56 µM
Hemolytic Cytotoxic
<5% Hemolysis | 1.56 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Shorter Antibacterial Peptide Having High Selectivity for E. coli Membranes and Low Potential for Inducing Resistance. | Microorganisms | 2020
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
14 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 14% Hemolysis=350µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2016 Dec 20 7:2006.