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Peptide record

TPDB09262

vCPP 0275 vCPP0275 Antibacterial Anticancer Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09262
vCPP 0275 vCPP0275
Antibacterial Anticancer Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 CPPsite3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
KKRYKKKYKAYKPYKKKKKF-NH2
Physicochemical Analysis
C131H215N35O25
NDCEQGHILMSTWV
K
2680.37
10.89
13
0
6
+13
8.08
-2.675
5.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5960
222.36
4
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
12
K
0
M
1
F
1
P
0
S
0
T
0
W
4
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 12 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 4 V: 0
Chemical Descriptors
20
C131H215N35O25
2680.37
10.89
+13
8.08
-2.675
Amidation
L
Linear
Linear
Free
Anticancer and Cell Penetrating
Capsid protein of the Torque teno douroucouli virus
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
IC50 = 44.8 ± 1.1 µM
Anticancer
44.8

Target

Breast Cancer
BT-20
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 34.0 ± 1.0 µM
Anticancer
34.0

Target

Breast Cancer
SK-BR-3
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 And BT-20 Cells BT-474 And SKBR3 Cells MCF 10A And HS68 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
In vitro
CCCGGGGCCSCCCCTTSSCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Staphylococcus aureus (S. aureus) and MRSA, Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa)

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L
Protein derived
In vitro
Additional Detail Fields 1 fields
CCCGGGGCCSCCCCTTSSCC