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Peptide record

TPDB09240

Antibacterial Anticancer Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09240
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
PMKKLKLALRLAAKIAPVW
Physicochemical Analysis
C103H179N27O20S1
NDCEQGHFSTY
ALK
2147.78
11.80
5
0
12
+5
0.43
0.463
138.95
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
256.08
0
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
4
K
1
M
0
F
2
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 4 M: 1 F: 0 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
19
C103H179N27O20S1
2147.78
11.80
+5
0.43
0.463
Evidence Records 4 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse fibroblasts 3T3-L1

Target

Mouse fibroblasts 3T3-L1

Source & Reference

NA
DBAASP
A Computationally Designed Peptide Derived From Escherichia Coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies | ACS Infect Dis | 2018
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
A Computationally Designed Peptide Derived From Escherichia Coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies | ACS Infect Dis | 2018
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Computationally Designed Peptide Derived From Escherichia Coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies | ACS Infect Dis | 2018
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Not active up to 100 µM | Cytotoxicity: 3T3-L1: Not active up to 100 µM HUVEC: Not active up to 100 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Infect Dis. 2018 Dec 14 4(12):1727-1736.