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Peptide record

TPDB09218

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09218
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLWGLIPGAISAVTSLIKK
Physicochemical Analysis
C98H160N22O23
RNDCEQHMY
IL
2014.48
10.60
2
0
11
+2
-3.01
1.163
148.95
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
273.02
3
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
2
K
0
M
1
F
1
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 2 M: 0 F: 1 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
19
C98H160N22O23
2014.48
10.60
+2
-3.01
1.163
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5-32 µg/mL

Target

Staphylococcus aureus AB94004 MRSA

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus A
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

B. thuringiensis AB92037

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY9
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

B. subtilis AB91021

Source & Reference

dbAMP DRAMP

Other

against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular,
Evidence 4 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

M. luteus AB93113

Source & Reference

dbAMP DRAMP

Other

5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular, it is active against clinical iso
Evidence 5 Activity

Activity

MIC
Antibacterial
20 µg/mL

Target

Candida albicans AY93025

Source & Reference

dbAMP DRAMP

Other

(MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular, it is active against clinical isolates MRSA, penicillin-resistant S. epid
Evidence 6 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

E. faecium ATCC29212

Source & Reference

dbAMP DRAMP

Other

t clinical isolates MRSA, penicillin-resistant S. epidermidis at 10 ug/ml. active against E. faecium ATCC29212 (MIC 64 ug/ml), A. baumannii ATCC19606 (MIC 16 ug/ml). However, the peptide is inactive against E.coli o
Evidence 7 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

A. baumannii ATCC19606

Source & Reference

dbAMP DRAMP

Other

resistant S. epidermidis at 10 ug/ml. active against E. faecium ATCC29212 (MIC 64 ug/ml), A. baumannii ATCC19606 (MIC 16 ug/ml). However, the peptide is inactive against E.coli or P.aeruginosa (>100 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
5-32 µg/mL

Target

Staphylococcus aureus AB94004 MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus A
Evidence 9 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

B. thuringiensis AB92037

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY9
Evidence 10 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

B. subtilis AB91021

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular,
Evidence 11 Activity

Activity

MIC
Antifungal
5 µg/mL

Target

M. luteus AB93113

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular, it is active against clinical iso
Evidence 12 Activity

Activity

MIC
Antifungal
20 µg/mL

Target

Candida albicans AY93025

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular, it is active against clinical isolates MRSA, penicillin-resistant S. epid
Evidence 13 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

E. faecium ATCC29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

t clinical isolates MRSA, penicillin-resistant S. epidermidis at 10 ug/ml. active against E. faecium ATCC29212 (MIC 64 ug/ml), A. baumannii ATCC19606 (MIC 16 ug/ml). However, the peptide is inactive against E.coli o
Evidence 14 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

A. baumannii ATCC19606

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

resistant S. epidermidis at 10 ug/ml. active against E. faecium ATCC29212 (MIC 64 ug/ml), A. baumannii ATCC19606 (MIC 16 ug/ml). However, the peptide is inactive against E.coli or P.aeruginosa (>100 ug/ml).
Evidence 15 Activity

Activity

MIC
Antiparasitic
5-32 µg/mL

Target

Staphylococcus aureus AB94004 MRSA

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus A
Evidence 16 Activity

Activity

MIC
Antiparasitic
10 µg/mL

Target

B. thuringiensis AB92037

Source & Reference

DRAMP

Other

Active against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY9
Evidence 17 Activity

Activity

MIC
Antiparasitic
10 µg/mL

Target

B. subtilis AB91021

Source & Reference

DRAMP

Other

against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular,
Evidence 18 Activity

Activity

MIC
Antiparasitic
5 µg/mL

Target

M. luteus AB93113

Source & Reference

DRAMP

Other

5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular, it is active against clinical iso
Evidence 19 Activity

Activity

MIC
Antiparasitic
20 µg/mL

Target

Candida albicans AY93025

Source & Reference

DRAMP

Other

(MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular, it is active against clinical isolates MRSA, penicillin-resistant S. epid
Evidence 20 Activity

Activity

MIC
Antiparasitic
64 µg/mL

Target

E. faecium ATCC29212

Source & Reference

DRAMP

Other

t clinical isolates MRSA, penicillin-resistant S. epidermidis at 10 ug/ml. active against E. faecium ATCC29212 (MIC 64 ug/ml), A. baumannii ATCC19606 (MIC 16 ug/ml). However, the peptide is inactive against E.coli o
Evidence 21 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

A. baumannii ATCC19606

Source & Reference

DRAMP

Other

resistant S. epidermidis at 10 ug/ml. active against E. faecium ATCC29212 (MIC 64 ug/ml), A. baumannii ATCC19606 (MIC 16 ug/ml). However, the peptide is inactive against E.coli or P.aeruginosa (>100 ug/ml).
Evidence 22 Activity

Activity

MIC
Antiviral
5-32 µg/mL

Target

Staphylococcus aureus AB94004 MRSA

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus A
Evidence 23 Activity

Activity

MIC
Antiviral
10 µg/mL

Target

B. thuringiensis AB92037

Source & Reference

DRAMP

Other

Active against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY9
Evidence 24 Activity

Activity

MIC
Antiviral
10 µg/mL

Target

B. subtilis AB91021

Source & Reference

DRAMP

Other

against S. aureus AB94004 MRSA (MIC 5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular,
Evidence 25 Activity

Activity

MIC
Antiviral
5 µg/mL

Target

M. luteus AB93113

Source & Reference

DRAMP

Other

5-32 ug/ml), B. thuringiensis AB92037 (MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular, it is active against clinical iso
Evidence 26 Activity

Activity

MIC
Antiviral
20 µg/mL

Target

Candida albicans AY93025

Source & Reference

DRAMP

Other

(MIC 10 ug/ml), B. subtilis AB91021 (MIC 10 ug/ml), M. luteus AB93113 (MIC 5 ug/ml), and C. albicans AY93025 (MIC 20 ug/ml). In particular, it is active against clinical isolates MRSA, penicillin-resistant S. epid
Evidence 27 Activity

Activity

MIC
Antiviral
64 µg/mL

Target

E. faecium ATCC29212

Source & Reference

DRAMP

Other

t clinical isolates MRSA, penicillin-resistant S. epidermidis at 10 ug/ml. active against E. faecium ATCC29212 (MIC 64 ug/ml), A. baumannii ATCC19606 (MIC 16 ug/ml). However, the peptide is inactive against E.coli o
Evidence 28 Activity

Activity

MIC
Antiviral
16 µg/mL

Target

A. baumannii ATCC19606

Source & Reference

DRAMP

Other

resistant S. epidermidis at 10 ug/ml. active against E. faecium ATCC29212 (MIC 64 ug/ml), A. baumannii ATCC19606 (MIC 16 ug/ml). However, the peptide is inactive against E.coli or P.aeruginosa (>100 ug/ml).
Evidence 29 Activity

Activity

10% Hemolysis
Toxicity
30 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 30 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of the scorpion venom-derived antimicrobial peptide Hp1404 as a new antimicrobial agent against carbapenem-resistant Acinetobacter baumannii. | Microb Pathog | 2021
Evidence 30 Activity

Activity

90.6±11.8% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
90.6±11.8% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationicity Enhancement on the Hydrophilic Face of Ctriporin Significantly Reduces Its Hemolytic Activity and Improves the Antimicrobial Activity against Antibiotic-Resistant ESKAPE Pathogens. | Toxins (Basel) | 2024
Evidence 31 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.