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Peptide record

TPDB09208

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09208
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFGKAFHSVSNFAKKHKTA
Physicochemical Analysis
C95H144N28O24
RDCEQILMPWY
K
2062.36
11.00
6
0
7
+4
2.89
-0.558
31.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
2
H
0
I
0
L
4
K
0
M
3
F
0
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 0 K: 4 M: 0 F: 3 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C95H144N28O24
2062.36
11.00
+4
2.89
-0.558
Evidence Records 25 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug
Evidence 2 Activity

Activity

MIC
Antibacterial
1-2 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug
Evidence 3 Activity

Activity

MIC
Antibacterial
1-2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant stra
Evidence 4 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

oli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MI
Evidence 5 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

L. monocytogenes

Source & Reference

dbAMP DRAMP

Other

yphimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MIC 1 ug/ml), and C. albicans (MIC
Evidence 6 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

E. faecium

Source & Reference

dbAMP DRAMP

Other

(MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MIC 1 ug/ml), and C. albicans (MIC ~36 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
1-2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug
Evidence 8 Activity

Activity

MIC
Antifungal
1-2 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP Antifungipept

Other

killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug
Evidence 9 Activity

Activity

MIC
Antifungal
1-2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP Antifungipept

Other

killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant stra
Evidence 10 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

oli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MI
Evidence 11 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

L. monocytogenes

Source & Reference

dbAMP DRAMP Antifungipept

Other

yphimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MIC 1 ug/ml), and C. albicans (MIC
Evidence 12 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

E. faecium

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MIC 1 ug/ml), and C. albicans (MIC ~36 ug/ml).
Evidence 13 Activity

Activity

MIC
Antiparasitic
1-2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug
Evidence 14 Activity

Activity

MIC
Antiparasitic
1-2 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP 3.0 DRAMP

Other

killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug
Evidence 15 Activity

Activity

MIC
Antiparasitic
1-2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant stra
Evidence 16 Activity

Activity

MIC
Antiparasitic
3 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

oli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MI
Evidence 17 Activity

Activity

MIC
Antiparasitic
1 µg/mL

Target

L. monocytogenes

Source & Reference

dbAMP 3.0 DRAMP

Other

yphimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MIC 1 ug/ml), and C. albicans (MIC
Evidence 18 Activity

Activity

MIC
Antiparasitic
1 µg/mL

Target

E. faecium

Source & Reference

dbAMP 3.0 DRAMP

Other

(MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MIC 1 ug/ml), and C. albicans (MIC ~36 ug/ml).
Evidence 19 Activity

Activity

MIC
Antiviral
1-2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug
Evidence 20 Activity

Activity

MIC
Antiviral
1-2 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug
Evidence 21 Activity

Activity

MIC
Antiviral
1-2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

killed E. coli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant stra
Evidence 22 Activity

Activity

MIC
Antiviral
3 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

oli (MIC 1-2 ug/ml), S. typhimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MI
Evidence 23 Activity

Activity

MIC
Antiviral
1 µg/mL

Target

L. monocytogenes

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

yphimurium (MIC 1-2 ug/ml), P. aeruginosa (MIC 1-2 ug/ml), Gram+ S. aureus (MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MIC 1 ug/ml), and C. albicans (MIC
Evidence 24 Activity

Activity

MIC
Antiviral
1 µg/mL

Target

E. faecium

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

(MIC 3 ug/ml), L. monocytogenes (MIC 1 ug/ml), vancomycin-resistant strain (anti-VRE) of E. faecium (MIC 1 ug/ml), and C. albicans (MIC ~36 ug/ml).
Evidence 25 Activity

Activity

50% Cell death
Toxicity
>48.5 µM
Cytotoxic
50% Cell death | >48.5 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010