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Peptide record

TPDB09205

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09205
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 SATPdb iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFRLLFHGVHHVGKIKPRA
Physicochemical Analysis
C109H167N33O20
NDCEQMSTWY
HF
2259.73
12.42
7
0
9
+4
2.10
0.100
97.37
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
3
H
1
I
2
L
2
K
0
M
3
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 3 I: 1 L: 2 K: 2 M: 0 F: 3 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
19
C109H167N33O20
2259.73
12.42
+4
2.10
0.100
Evidence Records 24 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against A-salmonicida 99-1 (MIC >64 uM), A. salmonicida 97-4 (MIC 32 uM), S. enterica serovar Typhimurium MS7953s (MIC 16 uM), S-enterica serovar Typhimurium 1402
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

dbAMP DRAMP

Other

Active against A-salmonicida 99-1 (MIC >64 uM), A. salmonicida 97-4 (MIC 32 uM), S. enterica serovar Typhimurium MS7953s (MIC 16 uM), S-enterica serovar Typhimurium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. a
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

dbAMP DRAMP

Other

ovar Typhimurium MS7953s (MIC 16 uM), S-enterica serovar Typhimurium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermi
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

dbAMP DRAMP

Other

uM), S-enterica serovar Typhimurium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicil
Evidence 5 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

dbAMP DRAMP

Other

murium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicillin-resistant S. aureus MRSA C623 (MIC 64 uM),
Evidence 6 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus epidermidis C621

Source & Reference

dbAMP DRAMP

Other

(MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicillin-resistant S. aureus MRSA C623 (MIC 64 uM), C-albicans C627 (MIC >64 uM). Upd
Evidence 7 Activity

Activity

MIC
Antibacterial
64 µM

Target

Staphylococcus aureus MRSA C623

Source & Reference

dbAMP DRAMP

Other

4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicillin-resistant S. aureus MRSA C623 (MIC 64 uM), C-albicans C627 (MIC >64 uM). Updated 7/2021
Evidence 8 Activity

Activity

MIC
Antifungal
32 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against A-salmonicida 99-1 (MIC >64 uM), A. salmonicida 97-4 (MIC 32 uM), S. enterica serovar Typhimurium MS7953s (MIC 16 uM), S-enterica serovar Typhimurium 1402
Evidence 9 Activity

Activity

MIC
Antifungal
16 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against A-salmonicida 99-1 (MIC >64 uM), A. salmonicida 97-4 (MIC 32 uM), S. enterica serovar Typhimurium MS7953s (MIC 16 uM), S-enterica serovar Typhimurium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. a
Evidence 10 Activity

Activity

MIC
Antifungal
32 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ovar Typhimurium MS7953s (MIC 16 uM), S-enterica serovar Typhimurium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermi
Evidence 11 Activity

Activity

MIC
Antifungal
8 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), S-enterica serovar Typhimurium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicil
Evidence 12 Activity

Activity

MIC
Antifungal
32 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

murium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicillin-resistant S. aureus MRSA C623 (MIC 64 uM),
Evidence 13 Activity

Activity

MIC
Antifungal
32 µM

Target

Staphylococcus epidermidis C621

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicillin-resistant S. aureus MRSA C623 (MIC 64 uM), C-albicans C627 (MIC >64 uM). Upd
Evidence 14 Activity

Activity

MIC
Antifungal
64 µM

Target

Staphylococcus aureus MRSA C623

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicillin-resistant S. aureus MRSA C623 (MIC 64 uM), C-albicans C627 (MIC >64 uM). Updated 7/2021
Evidence 15 Activity

Activity

MIC
Antiparasitic
32 µM

Target

A. salmonicida 97-4

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against A-salmonicida 99-1 (MIC >64 uM), A. salmonicida 97-4 (MIC 32 uM), S. enterica serovar Typhimurium MS7953s (MIC 16 uM), S-enterica serovar Typhimurium 1402
Evidence 16 Activity

Activity

MIC
Antiparasitic
16 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

DRAMP

Other

Active against A-salmonicida 99-1 (MIC >64 uM), A. salmonicida 97-4 (MIC 32 uM), S. enterica serovar Typhimurium MS7953s (MIC 16 uM), S-enterica serovar Typhimurium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. a
Evidence 17 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

DRAMP

Other

ovar Typhimurium MS7953s (MIC 16 uM), S-enterica serovar Typhimurium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermi
Evidence 18 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

DRAMP

Other

uM), S-enterica serovar Typhimurium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicil
Evidence 19 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

DRAMP

Other

murium 14028s (MIC >64 uM), P. aeruginosa K799 (MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicillin-resistant S. aureus MRSA C623 (MIC 64 uM),
Evidence 20 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Staphylococcus epidermidis C621

Source & Reference

DRAMP

Other

(MIC 32 uM), P. aeruginosa Z61 (MIC 8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicillin-resistant S. aureus MRSA C623 (MIC 64 uM), C-albicans C627 (MIC >64 uM). Upd
Evidence 21 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Staphylococcus aureus MRSA C623

Source & Reference

DRAMP

Other

4908 or UB1005 or DC2 (MIC 32 uM), S. epidermidis C621 (MIC 32 uM), methicillin-resistant S. aureus MRSA C623 (MIC 64 uM), C-albicans C627 (MIC >64 uM). Updated 7/2021
Evidence 22 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 23 Activity

Activity

>10% Killing
Toxicity
25 µM
Cytotoxic
>10% Killing | 25 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 24 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.