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Peptide record

TPDB09203

HP(2-20) Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09203
HP(2-20)
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb DBAASP
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AKKVFKRLEKLFSKIQNDK
Physicochemical Analysis
C107H182N30O27
CGHMPTWY
K
2320.81
10.82
7
2
7
+5
7.34
-1.000
82.11
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
1
R
1
N
1
D
0
C
1
E
1
Q
0
G
0
H
1
I
2
L
6
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 2 K: 6 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C107H182N30O27
2320.81
10.82
+5
7.34
-1.000
Evidence Records 33 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. v
Evidence 2 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P.
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. alb
Evidence 5 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP

Other

uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T.
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S.
Evidence 7 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S. cerevisiae (MIC 12.5-25 uM) at 28oC and 37oC ( Jang
Evidence 8 Activity

Activity

MIC
Antibacterial
6.25-25 um

Target

T. beigelii

Source & Reference

dbAMP DRAMP

Other

uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S. cerevisiae (MIC 12.5-25 uM) at 28oC and 37oC ( Jang et al., 2004 . It has a nemat
Evidence 9 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

M). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S. cerevisiae (MIC 12.5-25 uM) at 28oC and 37oC ( Jang et al., 2004 . It has a nematocidal activity against eggs and wor
Evidence 10 Activity

Activity

MIC
Antifungal
3.12 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. v
Evidence 11 Activity

Activity

MIC
Antifungal
3.12 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P.
Evidence 12 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. alb
Evidence 14 Activity

Activity

MIC
Antifungal
6.25 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T.
Evidence 15 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S.
Evidence 16 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S. cerevisiae (MIC 12.5-25 uM) at 28oC and 37oC ( Jang
Evidence 17 Activity

Activity

MIC
Antifungal
6.25-25 um

Target

T. beigelii

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S. cerevisiae (MIC 12.5-25 uM) at 28oC and 37oC ( Jang et al., 2004 . It has a nemat
Evidence 18 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S. cerevisiae (MIC 12.5-25 uM) at 28oC and 37oC ( Jang et al., 2004 . It has a nematocidal activity against eggs and wor
Evidence 19 Activity

Activity

MIC
Antiparasitic
3.12 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against Gram+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. v
Evidence 20 Activity

Activity

MIC
Antiparasitic
3.12 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

active against Gram+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P.
Evidence 21 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

active against Gram+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM).
Evidence 22 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

+ B. subtilis (MIC 3.12 uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. alb
Evidence 23 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

P. vulgaris

Source & Reference

DRAMP

Other

uM), S. epidermidis (MIC 3.12 uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T.
Evidence 24 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

uM), S. aureus (MIC 12.5 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S.
Evidence 25 Activity

Activity

MIC
Antiparasitic
12.5-25 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

.5 uM), P. vulgaris (MIC 6.25 uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S. cerevisiae (MIC 12.5-25 uM) at 28oC and 37oC ( Jang
Evidence 26 Activity

Activity

MIC
Antiparasitic
6.25-25 um

Target

T. beigelii

Source & Reference

DRAMP

Other

uM), and P. aeruginosa (MIC 12.5 uM). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S. cerevisiae (MIC 12.5-25 uM) at 28oC and 37oC ( Jang et al., 2004 . It has a nemat
Evidence 27 Activity

Activity

MIC
Antiparasitic
12.5-25 µM

Target

S. cerevisiae

Source & Reference

DRAMP

Other

M). Fungi: active against C. albicans (MIC 12.5-25 uM), T. beigelii (MIC 6.25-25 um), and S. cerevisiae (MIC 12.5-25 uM) at 28oC and 37oC ( Jang et al., 2004 . It has a nematocidal activity against eggs and wor
Evidence 28 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 29 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Evidence 30 Activity

Activity

0% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
0% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori. | Biochem J | 2006
Evidence 31 Activity

Activity

0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel short AMP: design and activity study. | Protein Pept Lett | 2012
Evidence 32 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Swiss_Prot Entry P56029]Non-hemolytic against mammalian cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2006 Feb 15 394(Pt 1):105-114.##Submitted (SEP-2004) to the PDB data bank.##To be published
Evidence 33 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP