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Peptide record

TPDB09199

Drosocin (unglycosyl Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09199
Drosocin (unglycosyl
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia AFP-GFuse Antifp Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP DRAVP 2.0 B3Pred BBPpredict ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GKPRPYSPRPTSHPRPIRV
Physicochemical Analysis
C98H160N34O24
ANDCEQLMFW
P
2198.56
12.41
6
0
3
+5
7.12
-1.579
35.79
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
67.77
4
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
0
L
1
K
0
M
0
F
6
P
2
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 0 K: 1 M: 0 F: 0 P: 6 S: 2 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
19
C98H160N34O24
2198.56
12.41
+5
7.12
-1.579
Linear
Similarity
Gly-Lys-Pro-Arg-Pro-Tyr-Ser-Pro-Arg-Pro-Thr-Ser-His-Pro-Arg-Pro-Ile-Arg-Val
Evidence Records 18 records
Evidence 1 Activity

Activity

IC50
Antibacterial
1 µM

Target

F. graminearum

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity against F. graminearum (IC50 1 uM), P. indica and R. solani (IC50 <20 uM). It is induced via the IMD pathway.
Evidence 2 Activity

Activity

IC50
Antibacterial
<20 µM

Target

R. solani

Source & Reference

dbAMP DRAMP

Other

Activity against F. graminearum (IC50 1 uM), P. indica and R. solani (IC50 <20 uM). It is induced via the IMD pathway.
Evidence 3 Activity

Activity

IC50
Antifungal
1 µM

Target

F. graminearum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity against F. graminearum (IC50 1 uM), P. indica and R. solani (IC50 <20 uM). It is induced via the IMD pathway.
Evidence 4 Activity

Activity

IC50
Antifungal
<20 µM

Target

R. solani

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Activity against F. graminearum (IC50 1 uM), P. indica and R. solani (IC50 <20 uM). It is induced via the IMD pathway.
Evidence 5 Activity

Activity

IC50
Antiparasitic
1 µM

Target

F. graminearum

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Activity against F. graminearum (IC50 1 uM), P. indica and R. solani (IC50 <20 uM). It is induced via the IMD pathway.
Evidence 6 Activity

Activity

IC50
Antiparasitic
<20 µM

Target

R. solani

Source & Reference

dbAMP 3.0 DRAMP

Other

Activity against F. graminearum (IC50 1 uM), P. indica and R. solani (IC50 <20 uM). It is induced via the IMD pathway.
Evidence 7 Activity

Activity

IC50
Antiviral
1 µM

Target

F. graminearum

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Activity against F. graminearum (IC50 1 uM), P. indica and R. solani (IC50 <20 uM). It is induced via the IMD pathway.
Evidence 8 Activity

Activity

IC50
Antiviral
<20 µM

Target

R. solani

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Activity against F. graminearum (IC50 1 uM), P. indica and R. solani (IC50 <20 uM). It is induced via the IMD pathway.
Evidence 9 Activity

Activity

Blood-Brain Barrier
0.217 min-1

Assay & Model

Efflux study ICU
Origin/Source
Brain elemination rate constant

Source & Reference

NA
B3Pdb

Other

Gila monster
Permeability
Direct iodination
Evidence 10 Activity

Activity

Blood-Brain Barrier
33%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

Gila monster
Direct iodination
Evidence 11 Activity

Activity

Blood-Brain Barrier
67%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

Gila monster
Direct iodination
Evidence 12 Activity

Activity

Blood-Brain Barrier
0.00086 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Gila monster
Intravenous
Permeability
Direct iodination
Evidence 13 Activity

Activity

Blood-Brain Barrier
0.01962 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Gila monster
Intravenous
Permeability
Direct iodination
Evidence 14 Activity

Activity

50% Cell death
Toxicity
>45.5 µM
Cytotoxic
50% Cell death | >45.5 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010
Evidence 15 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Hydroxyproline substitutions stabilize non-glycosylated drosocin against serum proteases without challenging its antibacterial activity. | Protein Pept Lett | 2014
Evidence 16 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydroxyproline substitutions stabilize non-glycosylated drosocin against serum proteases without challenging its antibacterial activity. | Protein Pept Lett | 2014
Evidence 17 Activity

Activity

<10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<10% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019
Evidence 18 Activity

Activity

<10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<10% Hemolysis | 100 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019
Additional Detail Fields 1 fields
Intravenous