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Peptide record

TPDB09197

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09197
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia SATPdb Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AKKVFKRLEKLFSKIWNWK
Physicochemical Analysis
C120H189N31O24
DCQGHMPTY
K
2450.01
11.19
7
1
9
+6
1.83
-0.726
82.11
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
448.98
2
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
1
E
0
Q
0
G
0
H
1
I
2
L
6
K
0
M
2
F
0
P
1
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 6 M: 0 F: 2 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
19
C120H189N31O24
2450.01
11.19
+6
1.83
-0.726
Evidence Records 24 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.39 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram+ B. subtilis (MIC 0.39 uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. v
Evidence 2 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis (MIC 0.39 uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P.
Evidence 3 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis (MIC 0.39 uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

+ B. subtilis (MIC 0.39 uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. alb
Evidence 5 Activity

Activity

MIC
Antibacterial
0.39 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP

Other

uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. bei
Evidence 6 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. beigelii (MIC 3.12 uM), and S. cerev
Evidence 7 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. beigelii (MIC 3.12 uM), and S. cerevisiae (MIC 3.12-6.25 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

T. beigelii

Source & Reference

dbAMP DRAMP

Other

39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. beigelii (MIC 3.12 uM), and S. cerevisiae (MIC 3.12-6.25 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
3.12-6.25 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. beigelii (MIC 3.12 uM), and S. cerevisiae (MIC 3.12-6.25 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
0.39 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram+ B. subtilis (MIC 0.39 uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. v
Evidence 11 Activity

Activity

MIC
Antifungal
0.78 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram+ B. subtilis (MIC 0.39 uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P.
Evidence 12 Activity

Activity

MIC
Antifungal
0.78 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram+ B. subtilis (MIC 0.39 uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
1.56 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

+ B. subtilis (MIC 0.39 uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. alb
Evidence 14 Activity

Activity

MIC
Antifungal
0.39 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), S. epidermidis (MIC 0.78 uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. bei
Evidence 15 Activity

Activity

MIC
Antifungal
1.56 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), S. aureus (MIC 0.78 uM), Gram- E. coli (MIC 1.56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. beigelii (MIC 3.12 uM), and S. cerev
Evidence 16 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

56 uM), P. vulgaris (MIC 0.39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. beigelii (MIC 3.12 uM), and S. cerevisiae (MIC 3.12-6.25 uM).
Evidence 17 Activity

Activity

MIC
Antifungal
3.12 µM

Target

T. beigelii

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

39 uM), and P. aeruginosa (MIC 1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. beigelii (MIC 3.12 uM), and S. cerevisiae (MIC 3.12-6.25 uM).
Evidence 18 Activity

Activity

MIC
Antifungal
3.12-6.25 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1.56 uM). Fungi: active against C. albicans (MIC 6.25 uM), T. beigelii (MIC 3.12 uM), and S. cerevisiae (MIC 3.12-6.25 uM).
Evidence 19 Activity

Activity

23% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
23% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Amphipathic alpha-helical peptide, HP (2-20), and its analogues derived from Helicobacter pylori: pore formation mechanism in various lipid compositions. | Biochim Biophys Acta | 2008
Evidence 20 Activity

Activity

0% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
0% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori. | Biochem J | 2006
Evidence 21 Activity

Activity

10% Hemolysis
Toxicity
49.2 µM
Hemolytic Cytotoxic
10% Hemolysis | 49.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A helix-PXXP-helix peptide with antibacterial activity without cytotoxicity against MDRPA-infected mice. | Biomaterials | 2014
Evidence 22 Activity

Activity

50% Hemolysis
Toxicity
397.7 µM
Hemolytic Cytotoxic
50% Hemolysis | 397.7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A helix-PXXP-helix peptide with antibacterial activity without cytotoxicity against MDRPA-infected mice. | Biomaterials | 2014
Evidence 23 Activity

Activity

EC50
Toxicity
64.4 µM
Cytotoxic
EC50 | 64.4 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A helix-PXXP-helix peptide with antibacterial activity without cytotoxicity against MDRPA-infected mice. | Biomaterials | 2014
Evidence 24 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis