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Peptide record

TPDB09152

Antibacterial Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09152
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
GIGAVLKVLALISWIKRKR
Physicochemical Analysis
C100H177N29O21
NDCEQHMFPTY
ILK
2121.69
12.43
5
0
11
+5
0.08
0.721
164.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
259.23
1
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
3
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
19
C100H177N29O21
2121.69
12.43
+5
0.08
0.721
Evidence Records 3 records
Evidence 1 Activity

Activity

28% Hemolysis
Toxicity
0.4 µM
Hemolytic Cytotoxic
28% Hemolysis | 0.4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Micelle-bound structures and dynamics of the hinge deleted analog of melittin and its diastereomer: implications in cell selective lysis by D-amino acid containing antimicrobial peptides. | Biochim Biophys Acta | 2010
Evidence 2 Activity

Activity

42% Hemolysis
Toxicity
23 µM
Hemolytic Cytotoxic
42% Hemolysis | 23 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Micelle-bound structures and dynamics of the hinge deleted analog of melittin and its diastereomer: implications in cell selective lysis by D-amino acid containing antimicrobial peptides. | Biochim Biophys Acta | 2010
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis