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Peptide record

TPDB09150

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09150
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia dbACP Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFKDLLKGAAKALVKAVLF
Physicochemical Analysis
C96H161N23O22
RNCEQHIMPSTWY
ALK
1989.48
10.55
4
1
12
+3
0.17
0.868
133.68
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
4
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
0
I
4
L
4
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 4 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
19
C96H161N23O22
1989.48
10.55
+3
0.17
0.868
Evidence Records 5 records
Evidence 1 Activity

Activity

LC50
Hemolysis
22 µM
[Ref.18554256]Hemolysis against human erythrocytes (LC50=22 µM).

Target

human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Chem Biol Drug Des. 2008 Jul 72(1):58-64.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
22 µM
Hemolytic Cytotoxic
50% Hemolysis | 22 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7. | Chem Biol Drug Des | 2008
Evidence 3 Activity

Activity

50% Cell death
Toxicity
5 µM
Cytotoxic
50% Cell death | 5 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7. | Chem Biol Drug Des | 2008
Evidence 4 Activity

Activity

LC50
Toxicity
22 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.18554256]Hemolysis against human erythrocytes (LC50=22 µM). | Cytotoxicity: [Ref.18554256]Cytotoxicity:Mouse fibroblasts L929 (LC50=5 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2008 Jul 72(1):58-64.
Evidence 5 Hemolysis

Activity

22 µM
LC50
[Ref.18554256]Hemolysis against human erythrocytes (LC50=22 µM).
Hemolysis

Target

human erythrocytes

Source & Reference

HemoPI PD_Hemolysis
Chem Biol Drug Des. 2008 Jul 72(1):58-64.
DRAMP4
PD_Hemolysis