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Peptide record

TPDB09138

Antibacterial Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09138
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 19-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ANRLLEAYKMLLKFLGNLR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C104H175N29O25S1
DCQHIPSTWV
L
2263.77
10.71
4
1
11
+3
1.15
0.111
133.68
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
0.66
3
Residue Composition
number
2
A
2
R
2
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
6
L
2
K
1
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 2 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
19 reviewed residue count
C104H175N29O25S1 sequence-only estimate (linear, free termini)
2263.77 sequence-only estimate (linear, free termini)
10.71 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
1.15 sequence-only estimate (linear, free termini)
0.111 sequence-only estimate (linear, free termini)
Evidence Records 8 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
1-2 µM
Hemolytic Cytotoxic
0% Hemolysis | 1-2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 2 Activity

Activity

1.23±0.05% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
1.23±0.05% Hemolysis | 4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 3 Activity

Activity

4.19±0.78% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
4.19±0.78% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 4 Activity

Activity

7.01±3.48% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
7.01±3.48% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 5 Activity

Activity

28.33±4.77% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
28.33±4.77% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 6 Activity

Activity

46.44±7.63% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
46.44±7.63% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 7 Activity

Activity

68.42±5.45% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
68.42±5.45% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 8 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis