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Peptide record

TPDB09137

Antibacterial Antiparasitic Antiviral Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09137
Antibacterial Antiparasitic Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbAMP 3.0 AI4AVP DRAVP 2.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Antiparasitic, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
ALWKTMLKKLGTMALHAGK
Physicochemical Analysis
C96H164N26O22S2
RNDCEQIFPSYV
LK
2098.64
11.00
5
0
10
+4
0.16
0.132
97.89
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
262.07
2
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
0
I
4
L
4
K
2
M
0
F
0
P
0
S
2
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 4 K: 4 M: 2 F: 0 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 0
Chemical Descriptors
19
C96H164N26O22S2
2098.64
11.00
+4
0.16
0.132
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
80 µM
Cytotoxic
50% Cytotoxicity | 80 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
80 µM
Cytotoxic
50% Cytotoxicity | 80 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 4 Activity

Activity

HC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.20718719]human red cells:HC50>100 µM. | Cytotoxicity: [Ref.20718719]Vero cells:CC50=80 µM 293TT(embryonic human culture cells):CC50=80 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
APMIS. 2010 Sep 1 118(9):674-80.