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Peptide record

TPDB09133

Antibacterial Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09133
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ACPIFTKIQGTYRGKAKCK
Physicochemical Analysis
C94H157N27O24S2
NDEHLMSWV
K
2113.57
10.31
5
0
6
+5
2.59
-0.437
51.58
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1615
76.41
6
Residue Composition
number
2
A
1
R
0
N
0
D
2
C
0
E
1
Q
2
G
0
H
2
I
0
L
4
K
0
M
1
F
1
P
0
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 2 H: 0 I: 2 L: 0 K: 4 M: 0 F: 1 P: 1 S: 0 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
19
C94H157N27O24S2
2113.57
10.31
+5
2.59
-0.437
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli (LC 19 uM). LC=lethal concentration.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against E. coli (LC 19 uM). LC=lethal concentration.
Evidence 3 Activity

Activity

70% Hemolysis
Toxicity
7.5 µM
Hemolytic Cytotoxic
70% Hemolysis | 7.5 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Effects of increasing hydrophobicity by N-terminal myristoylation on the antibacterial and hemolytic activities of the C-terminal cationic segments of human-?-defensins 1-3. | Chem Biol Drug Des | 2018
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Effects of increasing hydrophobicity by N-terminal myristoylation on the antibacterial and hemolytic activities of the C-terminal cationic segments of human-?-defensins 1-3. | Chem Biol Drug Des | 2018
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis