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Peptide record

TPDB09099

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09099
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP CAFPdb dbAMP Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
FLSLIPKIAGGIAALAKHL
Physicochemical Analysis
C93H157N23O21
RNDCEQMTWYV
AL
1933.41
10.60
3
0
12
+2
-1.44
1.289
164.74
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
3
I
4
L
2
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 3 L: 4 K: 2 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C93H157N23O21
1933.41
10.60
+2
-1.44
1.289
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.14 µM

Target

Staphylococcus aureus NCTC 10788

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus NCTC 10788 (MIC 4.14 uM), MRSA NCTC 10788 (4.14 uM), E. faecalis NCTC 12697 (MIC 16.56 uM), E. coli NCTC 10418 (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
16.56 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

dbAMP

Other

Active against S. aureus NCTC 10788 (MIC 4.14 uM), MRSA NCTC 10788 (4.14 uM), E. faecalis NCTC 12697 (MIC 16.56 uM), E. coli NCTC 10418 (MIC 16.56 uM), C. albicans NCYC 1467 (MIC 2.07 uM). Antibiofilm agai
Evidence 3 Activity

Activity

MIC
Antibacterial
16.56 µM

Target

Escherichia coli NCTC 10418

Source & Reference

dbAMP

Other

TC 10788 (MIC 4.14 uM), MRSA NCTC 10788 (4.14 uM), E. faecalis NCTC 12697 (MIC 16.56 uM), E. coli NCTC 10418 (MIC 16.56 uM), C. albicans NCYC 1467 (MIC 2.07 uM). Antibiofilm against S. aureus MBEC = 4 uM.
Evidence 4 Activity

Activity

MIC
Antibacterial
2.07 µM

Target

Candida albicans NCYC 1467

Source & Reference

dbAMP

Other

0788 (4.14 uM), E. faecalis NCTC 12697 (MIC 16.56 uM), E. coli NCTC 10418 (MIC 16.56 uM), C. albicans NCYC 1467 (MIC 2.07 uM). Antibiofilm against S. aureus MBEC = 4 uM.
Evidence 5 Activity

Activity

MIC
Antifungal
4.14 µM

Target

Staphylococcus aureus NCTC 10788

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus NCTC 10788 (MIC 4.14 uM), MRSA NCTC 10788 (4.14 uM), E. faecalis NCTC 12697 (MIC 16.56 uM), E. coli NCTC 10418 (MI
Evidence 6 Activity

Activity

MIC
Antifungal
16.56 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

dbAMP CAFPdb

Other

Active against S. aureus NCTC 10788 (MIC 4.14 uM), MRSA NCTC 10788 (4.14 uM), E. faecalis NCTC 12697 (MIC 16.56 uM), E. coli NCTC 10418 (MIC 16.56 uM), C. albicans NCYC 1467 (MIC 2.07 uM). Antibiofilm agai
Evidence 7 Activity

Activity

MIC
Antifungal
16.56 µM

Target

Escherichia coli NCTC 10418

Source & Reference

dbAMP CAFPdb

Other

TC 10788 (MIC 4.14 uM), MRSA NCTC 10788 (4.14 uM), E. faecalis NCTC 12697 (MIC 16.56 uM), E. coli NCTC 10418 (MIC 16.56 uM), C. albicans NCYC 1467 (MIC 2.07 uM). Antibiofilm against S. aureus MBEC = 4 uM.
Evidence 8 Activity

Activity

MIC
Antifungal
2.07 µM

Target

Candida albicans NCYC 1467

Source & Reference

dbAMP CAFPdb

Other

0788 (4.14 uM), E. faecalis NCTC 12697 (MIC 16.56 uM), E. coli NCTC 10418 (MIC 16.56 uM), C. albicans NCYC 1467 (MIC 2.07 uM). Antibiofilm against S. aureus MBEC = 4 uM.
Evidence 9 Activity

Activity

10% Hemolysis
Toxicity
7.79 µM
Hemolytic Cytotoxic
10% Hemolysis | 7.79 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Phylloseptins that Defense against Gram-Positive Bacteria and Inhibit the Proliferation of the Non-Small Cell Lung Cancer Cell Line, from the Skin Secretions of Phyllomedusa Frogs. | Molecules | 2017
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
22.8 µM
Hemolytic Cytotoxic
50% Hemolysis | 22.8 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Phylloseptins that Defense against Gram-Positive Bacteria and Inhibit the Proliferation of the Non-Small Cell Lung Cancer Cell Line, from the Skin Secretions of Phyllomedusa Frogs. | Molecules | 2017
Evidence 11 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes: 10% Hemolysis=7.79µM 50% Hemolysis=22.8µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2017 Aug 29 22(9):1428.
Evidence 12 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis