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Peptide record

TPDB09096

Antibacterial Anticancer Antifungal Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09096
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
FLSLIPAAISAVSALANHF
Physicochemical Analysis
C92H144N22O24
RDCEQGKMTWY
A
1942.29
7.85
1
0
13
+0
-3.12
1.500
144.21
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
1
H
2
I
3
L
0
K
0
M
2
F
1
P
3
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 3 K: 0 M: 0 F: 2 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C92H144N22O24
1942.29
7.85
+0
-3.12
1.500
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32.97 µM

Target

Staphylococcus aureus or MRSA NCTC 12497

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus or MRSA NCTC 12497 (MIC 32.97 uM), MBEC =33 uM, E.faecalis NCTC 12697 (MIC 263.78 uM), E.coli NCTC 10418 (MIC >263.78 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
263.78 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

dbAMP

Other

Active against S. aureus or MRSA NCTC 12497 (MIC 32.97 uM), MBEC =33 uM, E.faecalis NCTC 12697 (MIC 263.78 uM), E.coli NCTC 10418 (MIC >263.78 uM), and C.albicans NCYC 1467 (MIC 131.89 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
>263.78 µM

Target

E.coli NCTC 10418

Source & Reference

dbAMP

Other

us or MRSA NCTC 12497 (MIC 32.97 uM), MBEC =33 uM, E.faecalis NCTC 12697 (MIC 263.78 uM), E.coli NCTC 10418 (MIC >263.78 uM), and C.albicans NCYC 1467 (MIC 131.89 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
131.89 µM

Target

C.albicans NCYC 1467

Source & Reference

dbAMP

Other

EC =33 uM, E.faecalis NCTC 12697 (MIC 263.78 uM), E.coli NCTC 10418 (MIC >263.78 uM), and C.albicans NCYC 1467 (MIC 131.89 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
32.97 µM

Target

Staphylococcus aureus or MRSA NCTC 12497

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus or MRSA NCTC 12497 (MIC 32.97 uM), MBEC =33 uM, E.faecalis NCTC 12697 (MIC 263.78 uM), E.coli NCTC 10418 (MIC >263.78 uM),
Evidence 6 Activity

Activity

MIC
Antifungal
263.78 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus or MRSA NCTC 12497 (MIC 32.97 uM), MBEC =33 uM, E.faecalis NCTC 12697 (MIC 263.78 uM), E.coli NCTC 10418 (MIC >263.78 uM), and C.albicans NCYC 1467 (MIC 131.89 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
>263.78 µM

Target

E.coli NCTC 10418

Source & Reference

dbAMP CAFPdb Antifungipept

Other

us or MRSA NCTC 12497 (MIC 32.97 uM), MBEC =33 uM, E.faecalis NCTC 12697 (MIC 263.78 uM), E.coli NCTC 10418 (MIC >263.78 uM), and C.albicans NCYC 1467 (MIC 131.89 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
131.89 µM

Target

C.albicans NCYC 1467

Source & Reference

dbAMP CAFPdb Antifungipept

Other

EC =33 uM, E.faecalis NCTC 12697 (MIC 263.78 uM), E.coli NCTC 10418 (MIC >263.78 uM), and C.albicans NCYC 1467 (MIC 131.89 uM).
Evidence 9 Activity

Activity

10% Hemolysis
Toxicity
76.5 µM
Hemolytic Cytotoxic
10% Hemolysis | 76.5 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Phylloseptins that Defense against Gram-Positive Bacteria and Inhibit the Proliferation of the Non-Small Cell Lung Cancer Cell Line, from the Skin Secretions of Phyllomedusa Frogs. | Molecules | 2017
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
109.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 109.5 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Phylloseptins that Defense against Gram-Positive Bacteria and Inhibit the Proliferation of the Non-Small Cell Lung Cancer Cell Line, from the Skin Secretions of Phyllomedusa Frogs. | Molecules | 2017
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
52.17 µM
Hemolytic Cytotoxic
50% Hemolysis | 52.17 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities. | Drug Des Devel Ther | 2019
Evidence 12 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes: 10% Hemolysis=76.5µM 50% Hemolysis=109.5µM 50% Hemolysis=52.17µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2017 Aug 29 22(9):1428.