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Peptide record

TPDB09092

Antibacterial Anticancer Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09092
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
LVIRTVIAGYNLYRAIKKK
Physicochemical Analysis
C104H179N29O24
DCEQHMFPSW
IK
2219.75
10.95
5
0
11
+5
1.03
0.274
143.68
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
2980
134.25
4
Residue Composition
number
2
A
2
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
2
L
3
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
19
C104H179N29O24
2219.75
10.95
+5
1.03
0.274
Evidence Records 4 records
Evidence 1 Activity

Activity

23% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
23% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>360 µM
Hemolytic Cytotoxic
50% Hemolysis | >360 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken | FASEB J | 2006
Evidence 3 Activity

Activity

50% Cell death
Toxicity
159 µM
Cytotoxic
50% Cell death | 159 | µM | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken | FASEB J | 2006
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
240 µM
Hemolytic Cytotoxic
10% Hemolysis | 240 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities. | Eur J Med Chem | 2019