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Peptide record

TPDB09070

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard

19 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09070

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 AFP-GFuse Antifungipept CAFPdb PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLFKLIPKAIKGLVKAIRK

FASTA

>TPDB09070|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=19
FLFKLIPKAIKGLVKAIRK

Formula C108H187N27O20

Absent Amino Acids NDCEQHMSTWY

Common Amino Acids K

Mass 2183.84

PI 11.85

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +6

Boman Index 1.08

Hydrophobicity 0.647

Aliphatic Index 148.95

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 5 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

Formula

C108H187N27O20

Mass

2183.84

11.85

Net Charge

Boman Index

1.08

Hydrophobicity

0.647

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism S. aurerus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against S. aurerus (MIC 4 ug/ml), E.coli (MIC 16 ug/ml), and C. albicans (MIC 4 ug/ml). Also inhibited four human cancer c

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aurerus (MIC 4 ug/ml), E.coli (MIC 16 ug/ml), and C. albicans (MIC 4 ug/ml). Also inhibited four human cancer cell lines, H460, MB435s

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aurerus (MIC 4 ug/ml), E.coli (MIC 16 ug/ml), and C. albicans (MIC 4 ug/ml). Also inhibited four human cancer cell lines, H460, MB435s, MCF-7 and PC3 at ~10 uM.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism S. aurerus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against S. aurerus (MIC 4 ug/ml), E.coli (MIC 16 ug/ml), and C. albicans (MIC 4 ug/ml). Also inhibited four human cancer c

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aurerus (MIC 4 ug/ml), E.coli (MIC 16 ug/ml), and C. albicans (MIC 4 ug/ml). Also inhibited four human cancer cell lines, H460, MB435s

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aurerus (MIC 4 ug/ml), E.coli (MIC 16 ug/ml), and C. albicans (MIC 4 ug/ml). Also inhibited four human cancer cell lines, H460, MB435s, MCF-7 and PC3 at ~10 uM.

Evidence 7 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 64 | µg/mL | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

AaeAP1 and AaeAP2: novel antimicrobial peptides from the venom of the scorpion, Androctonus aeneas: structural characterisation, molecular cloning of biosynthetic precursor-encoding cDNAs and engineering of analogues with enhanced antimicrobial and anticancer activities. | Toxins (Basel) | 2015

Evidence 8 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 %

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.25626077] 100% hemolysis at 32 µg/ml against horse red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Toxins (Basel). 2015 Jan 23 7(2):219-37. doi: 10.3390/toxins7020219.

Evidence 9 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis