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Peptide record

TPDB09068

Antibacterial Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09068
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 19-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
DIFGAIWPLALGALKNLIK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C100H161N23O23
RCEQHMSTYV
L
2053.52
9.88
2
1
12
+1
-1.08
0.989
159.47
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
5500
2.68
1
Residue Composition
number
3
A
0
R
1
N
1
D
0
C
0
E
0
Q
2
G
0
H
3
I
4
L
2
K
0
M
1
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 4 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
19 reviewed residue count
C100H161N23O23 sequence-only estimate (linear, free termini)
2053.52 sequence-only estimate (linear, free termini)
9.88 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-1.08 sequence-only estimate (linear, free termini)
0.989 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
50% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of N-terminus modifications on the biological activity, membrane interaction, and secondary structure of the antimicrobial peptide hylin-a1. | Biopolymers | 2011
Evidence 2 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis