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Peptide record

TPDB09066

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09066
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FLSLIPKIATGIAALAKHL
Physicochemical Analysis
C95H161N23O22
RNDCEQMWYV
AL
1977.46
10.60
3
0
12
+2
-1.31
1.274
164.74
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
3
I
4
L
2
K
0
M
1
F
1
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 3 L: 4 K: 2 M: 0 F: 1 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C95H161N23O22
1977.46
10.60
+2
-1.31
1.274
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus (MRSA) (MIC 2 uM), E. coli (MIC 8 uM), P. aeruginosa (MIC 32 uM), and C. albicans (MIC 2 uM). Provided by Chunfeng Wang.
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against S. aureus (MRSA) (MIC 2 uM), E. coli (MIC 8 uM), P. aeruginosa (MIC 32 uM), and C. albicans (MIC 2 uM). Provided by Chunfeng Wang.
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

e against S. aureus (MRSA) (MIC 2 uM), E. coli (MIC 8 uM), P. aeruginosa (MIC 32 uM), and C. albicans (MIC 2 uM). Provided by Chunfeng Wang.
Evidence 4 Activity

Activity

MIC
Antifungal
8 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus (MRSA) (MIC 2 uM), E. coli (MIC 8 uM), P. aeruginosa (MIC 32 uM), and C. albicans (MIC 2 uM). Provided by Chunfeng Wang.
Evidence 5 Activity

Activity

MIC
Antifungal
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MRSA) (MIC 2 uM), E. coli (MIC 8 uM), P. aeruginosa (MIC 32 uM), and C. albicans (MIC 2 uM). Provided by Chunfeng Wang.
Evidence 6 Activity

Activity

MIC
Antifungal
2 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

e against S. aureus (MRSA) (MIC 2 uM), E. coli (MIC 8 uM), P. aeruginosa (MIC 32 uM), and C. albicans (MIC 2 uM). Provided by Chunfeng Wang.
Evidence 7 Activity

Activity

100% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
100% Hemolysis | 64 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
PSN-PC: A Novel Antimicrobial and Anti-Biofilm Peptide from the Skin Secretion of Phyllomedusa-camba with Cytotoxicity on Human Lung Cancer Cell. | Molecules | 2017
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
23 µM
Hemolytic Cytotoxic
50% Hemolysis | 23 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
PSN-PC: A Novel Antimicrobial and Anti-Biofilm Peptide from the Skin Secretion of Phyllomedusa-camba with Cytotoxicity on Human Lung Cancer Cell. | Molecules | 2017
Evidence 9 Activity

Activity

IC50
Toxicity
51.83 µM
Cytotoxic
IC50 | 51.83 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
PSN-PC: A Novel Antimicrobial and Anti-Biofilm Peptide from the Skin Secretion of Phyllomedusa-camba with Cytotoxicity on Human Lung Cancer Cell. | Molecules | 2017
Evidence 10 Activity

Activity

IC50
Toxicity
51.83 µM
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes: 100% Hemolysis=64µM Horse erythrocytes=50% Hemolysis=23µM | Cytotoxicity: HMEC-1: IC50=51.83µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2017 Nov 7 22(11):1896.
Evidence 11 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.