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Peptide record

TPDB09064

Antibacterial Anticancer Antifungal Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09064
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFKDLLKGAKKALVKTVLF
Physicochemical Analysis
C100H170N24O23
RNCEQHIMPSWY
K
2076.60
10.71
5
1
10
+4
1.64
0.437
123.16
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
0
I
4
L
5
K
0
M
2
F
0
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 4 K: 5 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
19
C100H170N24O23
2076.60
10.71
+4
1.64
0.437
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7. | Chem Biol Drug Des | 2008
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>200 µM
Cytotoxic
50% Cell death | >200 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7. | Chem Biol Drug Des | 2008
Evidence 3 Activity

Activity

LC50
Toxicity
500 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: LC50>500 µM | Cytotoxicity: L929 fibroblast-derived cells: LC50>200 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2008 Jul 72(1):58-64.