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Peptide record

TPDB09060

Antibacterial Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09060
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IGKKFKRIVQRIKKFLRNL
Physicochemical Analysis
C112H197N35O22
ADCEHMPSTWY
K
2386.02
12.72
8
0
8
+8
4.15
-0.500
117.89
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
1
Q
1
G
0
H
3
I
2
L
5
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 5 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C112H197N35O22
2386.02
12.72
+8
4.15
-0.500
Evidence Records 4 records
Evidence 1 Activity

Activity

MHC10
Hemolysis
11.2 µM
[Ref.22521196] MHC10=11.2 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Peptides. 2012 Jun 35(2):239-247.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
11.2 µM
Hemolytic Cytotoxic
10% Hemolysis | 11.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37 | Peptides | 2012
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.22521196] MHC10=11.2 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jun 35(2):239-247.
Evidence 4 Hemolysis

Activity

11.2 µM
MHC10
[Ref.22521196] MHC10=11.2 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Peptides. 2012 Jun 35(2):239-247.
DRAMP4
PD_Hemolysis