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Peptide record

TPDB09058

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09058
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia SATPdb dbACP Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLFSLIPSAIAGLVSAIRN
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C94H153N23O24
DCEQHKMTWY
AILS
1989.39
11.05
1
0
12
+1
-0.74
1.458
154.21
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
3
A
1
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
3
L
0
K
0
M
2
F
1
P
3
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 0 M: 0 F: 2 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19 reviewed residue count
C94H153N23O24 sequence-only estimate (linear, free termini)
1989.39 sequence-only estimate (linear, free termini)
11.05 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-0.74 sequence-only estimate (linear, free termini)
1.458 sequence-only estimate (linear, free termini)
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against C. albicans (MIC 32 ug/ml), E.coli (MIC >512 ug/ml), and S. aureus (MIC 16 ug/ml). UPdated 7/2024
Evidence 2 Activity

Activity

MIC
Antibacterial
>512 µg/mL

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Active against C. albicans (MIC 32 ug/ml), E.coli (MIC >512 ug/ml), and S. aureus (MIC 16 ug/ml). UPdated 7/2024
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against C. albicans (MIC 32 ug/ml), E.coli (MIC >512 ug/ml), and S. aureus (MIC 16 ug/ml). UPdated 7/2024
Evidence 4 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against C. albicans (MIC 32 ug/ml), E.coli (MIC >512 ug/ml), and S. aureus (MIC 16 ug/ml). UPdated 7/2024
Evidence 5 Activity

Activity

MIC
Antifungal
>512 µg/mL

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C. albicans (MIC 32 ug/ml), E.coli (MIC >512 ug/ml), and S. aureus (MIC 16 ug/ml). UPdated 7/2024
Evidence 6 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C. albicans (MIC 32 ug/ml), E.coli (MIC >512 ug/ml), and S. aureus (MIC 16 ug/ml). UPdated 7/2024
Evidence 7 Activity

Activity

100% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
100% Hemolysis | 64 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
AaeAP1 and AaeAP2: novel antimicrobial peptides from the venom of the scorpion, Androctonus aeneas: structural characterisation, molecular cloning of biosynthetic precursor-encoding cDNAs and engineering of analogues with enhanced antimicrobial and anticancer activities. | Toxins (Basel) | 2015
Evidence 8 Activity

Activity

% Hemolysis
Toxicity
100 %
Hemolytic
Hemolytic_activity: [Ref.25626077] 100% hemolysis at 64 µg/ml against horse red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxins (Basel). 2015 Jan 23 7(2):219-37. doi: 10.3390/toxins7020219.
Evidence 9 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.