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Peptide record

TPDB09056

Antibacterial Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09056
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb HemoPI Hemolytic2
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KWLNALLHHGLNCAKGVLA
Physicochemical Analysis
C94H152N28O22S1
RDEQIMFPSTY
L
2058.48
9.90
4
0
10
+2
-0.57
0.432
133.68
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
267.19
3
Residue Composition
number
3
A
0
R
2
N
0
D
1
C
0
E
0
Q
2
G
2
H
0
I
5
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 5 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
19
C94H152N28O22S1
2058.48
9.90
+2
-0.57
0.432
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 2 ug/ml), M. luteus KCTC 9341 (MIC 4 ug/ml), vancomycin-resis
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

B. subtilis KCTC 2213

Source & Reference

dbAMP

Other

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 2 ug/ml), M. luteus KCTC 9341 (MIC 4 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 ant
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

M. luteus KCTC 9341

Source & Reference

dbAMP

Other

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 2 ug/ml), M. luteus KCTC 9341 (MIC 4 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 anti-VRE (MIC 4 ug/ml), multidrug-resi
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

E. faecium strain CCARM 5028 anti-VRE

Source & Reference

dbAMP

Other

subtilis KCTC 2213 (MIC 2 ug/ml), M. luteus KCTC 9341 (MIC 4 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 anti-VRE (MIC 4 ug/ml), multidrug-resistant L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

L. monocytogenes CCARM 2161

Source & Reference

dbAMP

Other

omycin-resistant E. faecium strain CCARM 5028 anti-VRE (MIC 4 ug/ml), multidrug-resistant L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoc
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Pseudomonas aeruginosa CCARM 2161 MDRPA

Source & Reference

dbAMP

Other

28 anti-VRE (MIC 4 ug/ml), multidrug-resistant L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 23
Evidence 7 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Escherichia coli KCTC 1039

Source & Reference

dbAMP

Other

L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCT
Evidence 8 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Klebsiella oxytoca KCTC 1686

Source & Reference

dbAMP

Other

4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), and 5 strains
Evidence 9 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Citrobacter freundii KCTC 2359

Source & Reference

dbAMP

Other

MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), and 5 strains C. albicans (MIC 8-16 ug/ml).
Evidence 10 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

S. enterica KCTC 2930

Source & Reference

dbAMP

Other

9 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), and 5 strains C. albicans (MIC 8-16 ug/ml).
Evidence 11 Activity

Activity

MIC
Antibacterial
8-16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP

Other

, C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), and 5 strains C. albicans (MIC 8-16 ug/ml).
Evidence 12 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 2 ug/ml), M. luteus KCTC 9341 (MIC 4 ug/ml), vancomycin-resis
Evidence 13 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

B. subtilis KCTC 2213

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 2 ug/ml), M. luteus KCTC 9341 (MIC 4 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 ant
Evidence 14 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

M. luteus KCTC 9341

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 2 ug/ml), M. luteus KCTC 9341 (MIC 4 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 anti-VRE (MIC 4 ug/ml), multidrug-resi
Evidence 15 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

E. faecium strain CCARM 5028 anti-VRE

Source & Reference

dbAMP CAFPdb Antifungipept

Other

subtilis KCTC 2213 (MIC 2 ug/ml), M. luteus KCTC 9341 (MIC 4 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 anti-VRE (MIC 4 ug/ml), multidrug-resistant L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161
Evidence 16 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

L. monocytogenes CCARM 2161

Source & Reference

dbAMP CAFPdb Antifungipept

Other

omycin-resistant E. faecium strain CCARM 5028 anti-VRE (MIC 4 ug/ml), multidrug-resistant L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoc
Evidence 17 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Pseudomonas aeruginosa CCARM 2161 MDRPA

Source & Reference

dbAMP CAFPdb Antifungipept

Other

28 anti-VRE (MIC 4 ug/ml), multidrug-resistant L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 23
Evidence 18 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Escherichia coli KCTC 1039

Source & Reference

dbAMP CAFPdb Antifungipept

Other

L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCT
Evidence 19 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Klebsiella oxytoca KCTC 1686

Source & Reference

dbAMP CAFPdb Antifungipept

Other

4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), and 5 strains
Evidence 20 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Citrobacter freundii KCTC 2359

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), and 5 strains C. albicans (MIC 8-16 ug/ml).
Evidence 21 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

S. enterica KCTC 2930

Source & Reference

dbAMP CAFPdb Antifungipept

Other

9 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), and 5 strains C. albicans (MIC 8-16 ug/ml).
Evidence 22 Activity

Activity

MIC
Antifungal
8-16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

, C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), and 5 strains C. albicans (MIC 8-16 ug/ml).
Evidence 23 Hemolysis

Source & Reference

HemoPI
NA