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Peptide record

TPDB09051

Antibacterial Antifungal Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09051
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 19-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RGRGKQGGKVRAKAKTRSS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C82H154N36O24
NDCEHILMFPWY
RGK
2028.35
12.89
8
0
3
+8
4.49
-1.747
25.79
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
4
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
1
Q
4
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
19 reviewed residue count
C82H154N36O24 sequence-only estimate (linear, free termini)
2028.35 sequence-only estimate (linear, free termini)
12.89 sequence-only estimate (linear, free termini)
+8 sequence-only estimate (linear, free termini)
4.49 sequence-only estimate (linear, free termini)
-1.747 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011