Back to search

Peptide record

TPDB09043

Antibacterial Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09043
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLSMIPKIAGGIASLVKNL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C92H158N22O23S1
RDCEQHTWY
IL
1972.46
10.60
2
0
11
+2
-1.04
1.163
148.95
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
2
K
1
M
1
F
1
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 2 M: 1 F: 1 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19 reviewed residue count
C92H158N22O23S1 sequence-only estimate (linear, free termini)
1972.46 sequence-only estimate (linear, free termini)
10.60 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
-1.04 sequence-only estimate (linear, free termini)
1.163 sequence-only estimate (linear, free termini)
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

E.coli

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 4 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 5 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

E.coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 6 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 16 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. | Toxins (Basel) | 2016
Evidence 8 Activity

Activity

4% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 32 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. | Toxins (Basel) | 2016
Evidence 9 Activity

Activity

15% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 64 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. | Toxins (Basel) | 2016
Evidence 10 Activity

Activity

55% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
55% Hemolysis | 128 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. | Toxins (Basel) | 2016
Evidence 11 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.