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Peptide record

TPDB09043

Antibacterial Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09043
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLSMIPKIAGGIASLVKNL
Physicochemical Analysis
C92H158N22O23S1
RDCEQHTWY
IL
1972.46
10.60
2
0
11
+2
-1.11
1.163
148.95
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
2
K
1
M
1
F
1
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 2 M: 1 F: 1 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C92H158N22O23S1
1972.46
10.60
+2
-1.11
1.163
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

E.coli

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 4 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 5 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

E.coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 6 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 8 ug/ml), E.coli (MIC 128 ug/ml)), C. albicans (MIC 16 ug/ml)). Updated 7/2021
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 16 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. | Toxins (Basel) | 2016
Evidence 8 Activity

Activity

4% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 32 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. | Toxins (Basel) | 2016
Evidence 9 Activity

Activity

15% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 64 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. | Toxins (Basel) | 2016
Evidence 10 Activity

Activity

55% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
55% Hemolysis | 128 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. | Toxins (Basel) | 2016
Evidence 11 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.