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Peptide record

TPDB09042

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09042
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLSLIPHIVSGVASLAKHF
Physicochemical Analysis
C98H154N24O23
RNDCEQMTWY
LS
2036.45
10.10
3
0
11
+1
-1.00
1.226
143.68
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
2
H
2
I
3
L
1
K
0
M
2
F
1
P
3
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 2 L: 3 K: 1 M: 0 F: 2 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
19
C98H154N24O23
2036.45
10.10
+1
-1.00
1.226
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus (MIC 6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus (MIC 6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. bauman
Evidence 3 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus (MIC 6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneum
Evidence 4 Activity

Activity

MIC
Antibacterial
25-30 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. pa
Evidence 5 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP

Other

IC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. c
Evidence 6 Activity

Activity

MIC
Antibacterial
25 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP

Other

1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite
Evidence 7 Activity

Activity

MIC
Antibacterial
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP

Other

0 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite L. infantum, L. major, and L. braziliensis (IC
Evidence 8 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

S. cerevisiae

Source & Reference

dbAMP

Other

uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite L. infantum, L. major, and L. braziliensis (IC50 13.3-18.5 uM).
Evidence 9 Activity

Activity

IC50
Antibacterial
13.3-18.5 µM

Target

L. braziliensis

Source & Reference

dbAMP

Other

C 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite L. infantum, L. major, and L. braziliensis (IC50 13.3-18.5 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus (MIC 6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli
Evidence 11 Activity

Activity

MIC
Antifungal
25 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus (MIC 6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. bauman
Evidence 12 Activity

Activity

MIC
Antifungal
1.56 µM

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus (MIC 6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneum
Evidence 13 Activity

Activity

MIC
Antifungal
25-30 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. pa
Evidence 14 Activity

Activity

MIC
Antifungal
6.25 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. c
Evidence 15 Activity

Activity

MIC
Antifungal
25 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite
Evidence 16 Activity

Activity

MIC
Antifungal
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite L. infantum, L. major, and L. braziliensis (IC
Evidence 17 Activity

Activity

MIC
Antifungal
6.25 µM

Target

S. cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite L. infantum, L. major, and L. braziliensis (IC50 13.3-18.5 uM).
Evidence 18 Activity

Activity

IC50
Antifungal
13.3-18.5 µM

Target

L. braziliensis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite L. infantum, L. major, and L. braziliensis (IC50 13.3-18.5 uM).
Evidence 19 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram+ S. aureus (MIC 6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli
Evidence 20 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP 3.0

Other

Active against Gram+ S. aureus (MIC 6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. bauman
Evidence 21 Activity

Activity

MIC
Antiparasitic
1.56 µM

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP 3.0

Other

Active against Gram+ S. aureus (MIC 6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneum
Evidence 22 Activity

Activity

MIC
Antiparasitic
25-30 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0

Other

6.25 uM), E. faecalis ATCC 29212 (MIC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. pa
Evidence 23 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP 3.0

Other

IC 25 uM), S. pyogenes ATCC 19615 (MIC 1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. c
Evidence 24 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP 3.0

Other

1.56 uM), Gram- E. coli ATCC 25922 (MIC 25-30 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite
Evidence 25 Activity

Activity

MIC
Antiparasitic
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP 3.0

Other

0 uM), A. baumannii ATCC 19606 (MIC 6.25 uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite L. infantum, L. major, and L. braziliensis (IC
Evidence 26 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0

Other

uM), K. pneumoniae ATCC 13883 (MIC 25 uM), yeast C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite L. infantum, L. major, and L. braziliensis (IC50 13.3-18.5 uM).
Evidence 27 Activity

Activity

IC50
Antiparasitic
13.3-18.5 µM

Target

L. braziliensis

Source & Reference

dbAMP 3.0

Other

C 22019 (MIC 50 uM), S. cerevisiae (MIC 6.25 uM), and parasite L. infantum, L. major, and L. braziliensis (IC50 13.3-18.5 uM).
Evidence 28 Activity

Activity

LC50
Hemolysis
25 µM
Human erythrocytes: LC50=25 µM

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
PLoS One. 2013 Aug 13 8(8):e70782.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 29 Activity

Activity

50% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
50% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure, antimicrobial activities and mode of interaction with membranes of novel [corrected] phylloseptins from the painted-belly leaf frog, Phyllomedusa sauvagii. | PLoS One | 2013
Evidence 30 Activity

Activity

LC50
Toxicity
25 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: LC50=25 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2013 Aug 13 8(8):e70782.
Evidence 31 Hemolysis

Activity

25 µM
LC50
Human erythrocytes: LC50=25 µM
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
PLoS One. 2013 Aug 13 8(8):e70782.
DRAMP4
PD_Hemolysis