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Peptide record

TPDB09041

Antibacterial Anticancer Antifungal Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09041
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FFSMIPKIAGGIASLVKNL
Physicochemical Analysis
C95H156N22O23S1
RDCEQHTWY
I
2006.48
10.60
2
0
11
+2
-1.68
1.111
128.42
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
2
L
2
K
1
M
2
F
1
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 2 K: 2 M: 1 F: 2 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C95H156N22O23S1
2006.48
10.60
+2
-1.68
1.111
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Toxicity
36.6 µM
Cytotoxic
IC50 | 36.6 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Phylloseptin-PBa--A Novel Broad-Spectrum Antimicrobial Peptide from the Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea) Which Exhibits Cancer Cell Cytotoxicity. | Toxins (Basel) | 2015
Evidence 2 Activity

Activity

1.4% Hemolysis
Toxicity
8 µg/mL
Hemolytic Cytotoxic
1.4% Hemolysis | 8 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Phylloseptin-PBa--A Novel Broad-Spectrum Antimicrobial Peptide from the Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea) Which Exhibits Cancer Cell Cytotoxicity. | Toxins (Basel) | 2015
Evidence 3 Activity

Activity

80% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
80% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Phylloseptin-PBa--A Novel Broad-Spectrum Antimicrobial Peptide from the Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea) Which Exhibits Cancer Cell Cytotoxicity. | Toxins (Basel) | 2015
Evidence 4 Activity

Activity

IC50
Toxicity
36.6 µM
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes: 1.4% Hemolysis=8µg/ml Human erythrocytes: 80% Hemolysis=128µg/ml | Cytotoxicity: HMEC-1: IC50=36.6µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxins (Basel). 2015 Dec 1 7(12):5182-93.