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Peptide record

TPDB09040

Antibacterial Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09040
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 19-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
AKKVFKRLPKLFSKIWNWK
Physicochemical Analysis
C120H189N31O22
DCEQGHMTY
K
2418.02
11.90
7
0
9
+7
0.26
-0.626
82.11
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
454.92
2
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
6
K
0
M
2
F
1
P
1
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 6 M: 0 F: 2 P: 1 S: 1 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
19
C120H189N31O22
2418.02
11.90
+7
0.26
-0.626
Evidence Records 4 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A proline-hinge alters the characteristics of the amphipathic ?-helical AMPs. | PLoS One | 2013
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
>800 µM
Hemolytic Cytotoxic
10% Hemolysis | >800 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A helix-PXXP-helix peptide with antibacterial activity without cytotoxicity against MDRPA-infected mice. | Biomaterials | 2014
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>800 µM
Hemolytic Cytotoxic
50% Hemolysis | >800 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A helix-PXXP-helix peptide with antibacterial activity without cytotoxicity against MDRPA-infected mice. | Biomaterials | 2014
Evidence 4 Activity

Activity

EC50
Toxicity
381.2 µM
Cytotoxic
EC50 | 381.2 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A helix-PXXP-helix peptide with antibacterial activity without cytotoxicity against MDRPA-infected mice. | Biomaterials | 2014