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Peptide record

TPDB09036

Antibacterial Anticancer Antifungal Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09036
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia SATPdb Antifungipept CAFPdb
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AKKVSKRLEKLFSKIQNDK
Physicochemical Analysis
C101H178N30O28
CGHMPTWY
K
2260.71
10.82
7
2
6
+5
8.60
-1.189
82.11
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
1
A
1
R
1
N
1
D
0
C
1
E
1
Q
0
G
0
H
1
I
2
L
6
K
0
M
1
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 2 K: 6 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C101H178N30O28
2260.71
10.82
+5
8.60
-1.189
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram+ B. subtilis (MIC 6.25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vul
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis (MIC 6.25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. ae
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis (MIC 6.25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). F
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

am+ B. subtilis (MIC 6.25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albic
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP

Other

25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigel
Evidence 6 Activity

Activity

MIC
Antibacterial
25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigelii (MIC 50 uM), and S. cerevisi
Evidence 7 Activity

Activity

MIC
Antibacterial
100 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigelii (MIC 50 uM), and S. cerevisiae (MIC 50-100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
50 µM

Target

T. beigelii

Source & Reference

dbAMP DRAMP

Other

12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigelii (MIC 50 uM), and S. cerevisiae (MIC 50-100 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
50-100 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

(MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigelii (MIC 50 uM), and S. cerevisiae (MIC 50-100 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
6.25 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram+ B. subtilis (MIC 6.25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vul
Evidence 11 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram+ B. subtilis (MIC 6.25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. ae
Evidence 12 Activity

Activity

MIC
Antifungal
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram+ B. subtilis (MIC 6.25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). F
Evidence 13 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

am+ B. subtilis (MIC 6.25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albic
Evidence 14 Activity

Activity

MIC
Antifungal
12.5 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

25 uM), S. epidermidis (MIC 12.5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigel
Evidence 15 Activity

Activity

MIC
Antifungal
25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 uM), S. aureus (MIC 50 uM), Gram- E. coli (MIC 12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigelii (MIC 50 uM), and S. cerevisi
Evidence 16 Activity

Activity

MIC
Antifungal
100 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

12.5 uM), P. vulgaris (MIC 12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigelii (MIC 50 uM), and S. cerevisiae (MIC 50-100 uM).
Evidence 17 Activity

Activity

MIC
Antifungal
50 µM

Target

T. beigelii

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

12.5 uM), and P. aeruginosa (MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigelii (MIC 50 uM), and S. cerevisiae (MIC 50-100 uM).
Evidence 18 Activity

Activity

MIC
Antifungal
50-100 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 25 uM). Fungi: active against C. albicans (MIC 100 uM), T. beigelii (MIC 50 uM), and S. cerevisiae (MIC 50-100 uM).
Evidence 19 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 20 Activity

Activity

0% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
0% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori. | Biochem J | 2006