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Peptide record

TPDB09032

Antibacterial Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09032
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 19-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FCPRRYKQIGTGLPGTKCK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C95H157N29O24S2
ANDEHMSWV
GK
2153.59
10.46
5
0
4
+5
2.06
-0.800
41.05
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1615
0.75
6
Residue Composition
number
0
A
2
R
0
N
0
D
2
C
0
E
1
Q
3
G
0
H
1
I
1
L
3
K
0
M
1
F
2
P
0
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 1 K: 3 M: 0 F: 1 P: 2 S: 0 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
19 reviewed residue count
C95H157N29O24S2 sequence-only estimate (linear, free termini)
2153.59 sequence-only estimate (linear, free termini)
10.46 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
2.06 sequence-only estimate (linear, free termini)
-0.800 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli (LC 19 uM). LC=lethal concentration.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against E. coli (LC 19 uM). LC=lethal concentration.
Evidence 3 Activity

Activity

15% Hemolysis
Toxicity
10-20 µM
Hemolytic Cytotoxic
15% Hemolysis | 10-20 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Effects of increasing hydrophobicity by N-terminal myristoylation on the antibacterial and hemolytic activities of the C-terminal cationic segments of human-?-defensins 1-3. | Chem Biol Drug Des | 2018
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Effects of increasing hydrophobicity by N-terminal myristoylation on the antibacterial and hemolytic activities of the C-terminal cationic segments of human-?-defensins 1-3. | Chem Biol Drug Des | 2018
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis