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Peptide record

TPDB09032

Antibacterial Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB09032
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FCPRRYKQIGTGLPGTKCK
Physicochemical Analysis
C95H157N29O24S2
ANDEHMSWV
GK
2153.59
10.46
5
0
4
+5
2.96
-0.800
41.05
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1615
74.99
6
Residue Composition
number
0
A
2
R
0
N
0
D
2
C
0
E
1
Q
3
G
0
H
1
I
1
L
3
K
0
M
1
F
2
P
0
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 1 K: 3 M: 0 F: 1 P: 2 S: 0 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
19
C95H157N29O24S2
2153.59
10.46
+5
2.96
-0.800
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli (LC 19 uM). LC=lethal concentration.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against E. coli (LC 19 uM). LC=lethal concentration.
Evidence 3 Activity

Activity

15% Hemolysis
Toxicity
10-20 µM
Hemolytic Cytotoxic
15% Hemolysis | 10-20 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Effects of increasing hydrophobicity by N-terminal myristoylation on the antibacterial and hemolytic activities of the C-terminal cationic segments of human-?-defensins 1-3. | Chem Biol Drug Des | 2018
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Effects of increasing hydrophobicity by N-terminal myristoylation on the antibacterial and hemolytic activities of the C-terminal cationic segments of human-?-defensins 1-3. | Chem Biol Drug Des | 2018
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis