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Peptide record

TPDB09018

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB09018
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RGWRRWGRKWAHGWKKYG
Physicochemical Analysis
C112H159N39O20
NDCEQILMFPSTV
RGW
2371.74
12.42
8
0
6
+7
-1.30
-2.089
5.56
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
23490
990.41
1
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
4
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 1 V: 0
Chemical Descriptors
18
C112H159N39O20
2371.74
12.42
+7
-1.30
-2.089
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>400 µM
Hemolytic Cytotoxic
50% Hemolysis | >400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Bacterial killing mechanism of sheep myeloid antimicrobial peptide-18 (SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity. | Amino Acids | 2014
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Bacterial killing mechanism of sheep myeloid antimicrobial peptide-18 (SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity. | Amino Acids | 2014