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Peptide record

TPDB09016

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB09016
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ITKVITKLLNRLTKILSK
Physicochemical Analysis
C96H180N26O24
ADCEQGHMFPWY
LK
2082.64
11.80
5
0
8
+5
2.64
0.356
167.78
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
5
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
4
L
4
K
0
M
0
F
0
P
1
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 4 K: 4 M: 0 F: 0 P: 0 S: 1 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C96H180N26O24
2082.64
11.80
+5
2.64
0.356
Evidence Records 3 records
Evidence 1 Activity

Activity

<=5% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
<=5% Hemolysis | 250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics. | ACS Infect Dis | 2019
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics. | ACS Infect Dis | 2019
Evidence 3 Activity

Activity

EC50
Toxicity
22.5
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31117348] 5% hemolysis at 250 µM against human blood cells. | Cytotoxicity: [Ref.31117348] ①The cell viability of MCF7 cells induced by peptide 2 is 94.2%, 88.6%, 82.0%, 55.0%, 44.0%, 32.4%, 15.3%, 15.8%, 12.8% and 1.2% at peptide concentrations of 1, 10, 15, 20, 25, 30, 35, 40, 50 and 100 µM. EC50=22.5±0.7 µM. ②The cell viability of Hela cells induced by peptide 2 is 96.1%, 95.4%, 83.8%, 64.2%, 57.7%, 49.5%, 31.5%, 30.2%, 7.8% and 0.2% at peptide concentrations of 1, 10, 15, 20, 25, 30, 35, 40, 50 and 100 µM. EC50=29.8±1 µM. ③The cell viabiity of HDF cells induced by peptide 2 is 96.3%, 89.7%, 89.9%, 92.7%, 95.0%, 93.4%, 93.1%, 96.1%, 88.6% and 67.4% at peptide concentrations of 1, 10, 15, 20, 25, 30, 35, 40, 50 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Infect Dis. 2019 May 30. doi: 10.1021/acsinfecdis.9b00157.