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Peptide record

TPDB08996

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08996
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GGLRSLGRKILRAWKKYG
Physicochemical Analysis
C94H159N31O21
NDCEQHMFPTV
G
2059.49
12.15
6
0
7
+6
0.62
-0.672
92.22
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
339.40
2
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
1
I
3
L
3
K
0
M
0
F
0
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 3 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
18
C94H159N31O21
2059.49
12.15
+6
0.62
-0.672
Evidence Records 32 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-1 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
1 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

nst E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP DRAMP

Other

MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM),
Evidence 5 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Staphylococcus aureus ATCC 25923 Cowan 1 or MRSA

Source & Reference

dbAMP DRAMP

Other

4028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16
Evidence 6 Activity

Activity

MIC
Antibacterial
1 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP

Other

S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
16 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

r MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
2 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

rmidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
0.5-1 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens
Evidence 11 Activity

Activity

MIC
Antifungal
2 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC
Evidence 12 Activity

Activity

MIC
Antifungal
1 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nst E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S
Evidence 13 Activity

Activity

MIC
Antifungal
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM),
Evidence 14 Activity

Activity

MIC
Antifungal
2-4 µM

Target

Staphylococcus aureus ATCC 25923 Cowan 1 or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

4028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16
Evidence 15 Activity

Activity

MIC
Antifungal
1 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
2 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 17 Activity

Activity

MIC
Antifungal
16 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

r MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 18 Activity

Activity

MIC
Antifungal
2 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

rmidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 19 Activity

Activity

MIC
Antiparasitic
0.5-1 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens
Evidence 20 Activity

Activity

MIC
Antiparasitic
2 µM

Target

S. typhimurium ATCC 14028

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC
Evidence 21 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

nst E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S
Evidence 22 Activity

Activity

MIC
Antiparasitic
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

DRAMP

Other

MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM),
Evidence 23 Activity

Activity

MIC
Antiparasitic
2-4 µM

Target

Staphylococcus aureus ATCC 25923 Cowan 1 or MRSA

Source & Reference

DRAMP

Other

4028 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16
Evidence 24 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

DRAMP

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 25 Activity

Activity

MIC
Antiparasitic
2 µM

Target

B. megaterium Bm11

Source & Reference

DRAMP

Other

S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 26 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

r MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 27 Activity

Activity

MIC
Antiparasitic
2 µM

Target

C. neoformans

Source & Reference

DRAMP

Other

rmidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 2 uM).
Evidence 28 Activity

Activity

60% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
60% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing Antibacterial Peptides with Enhanced Killing Kinetics. | Front Microbiol | 2018
Evidence 29 Activity

Activity

0.5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0.5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural insight into the mechanism of action of antimicrobial peptide BMAP-28(1-18) and its analogue mutBMAP18. | J Struct Biol | 2018
Evidence 30 Activity

Activity

1.9% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
1.9% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural insight into the mechanism of action of antimicrobial peptide BMAP-28(1-18) and its analogue mutBMAP18. | J Struct Biol | 2018
Evidence 31 Activity

Activity

4.1% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
4.1% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural insight into the mechanism of action of antimicrobial peptide BMAP-28(1-18) and its analogue mutBMAP18. | J Struct Biol | 2018
Evidence 32 Activity

Activity

0% Hemolysis
Toxicity
24.28 µM
Hemolytic Cytotoxic
0% Hemolysis | 24.28 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer Activities of Antimicrobial BmKn2 Peptides Against Oral and Colon Cancer Cells | Int J Pept Res Ther | 2014