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Peptide record

TPDB08994

Antibacterial Anticancer Antifungal Antiviral Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08994
Antibacterial Anticancer Antifungal Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb dbAMP 3.0 APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLFSLIPHAIGGLISAFK
Physicochemical Analysis
C96H147N21O21
RNDCEQMTWYV
ILF
1931.35
10.10
2
0
11
+1
-3.66
1.433
141.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
3
I
3
L
1
K
0
M
3
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 3 L: 3 K: 1 M: 0 F: 3 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C96H147N21O21
1931.35
10.10
+1
-3.66
1.433
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
20 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 20 uM) and C. albicans ( MIC 64 uM), and poorly active against E. coli (MIC 150 uM). It caused 2
Evidence 2 Activity

Activity

MIC
Antibacterial
150 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

ive against S. aureus (MIC 20 uM) and C. albicans ( MIC 64 uM), and poorly active against E. coli (MIC 150 uM). It caused 28% hemolysis at 100 uM (but 65% at 120 uM) and no hemolysis until 40 uM. AamA
Evidence 3 Activity

Activity

MIC
Antifungal
20 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 20 uM) and C. albicans ( MIC 64 uM), and poorly active against E. coli (MIC 150 uM). It caused 2
Evidence 4 Activity

Activity

MIC
Antifungal
150 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ive against S. aureus (MIC 20 uM) and C. albicans ( MIC 64 uM), and poorly active against E. coli (MIC 150 uM). It caused 28% hemolysis at 100 uM (but 65% at 120 uM) and no hemolysis until 40 uM. AamA
Evidence 5 Activity

Activity

MIC
Antiviral
20 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against S. aureus (MIC 20 uM) and C. albicans ( MIC 64 uM), and poorly active against E. coli (MIC 150 uM). It caused 2
Evidence 6 Activity

Activity

MIC
Antiviral
150 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

ive against S. aureus (MIC 20 uM) and C. albicans ( MIC 64 uM), and poorly active against E. coli (MIC 150 uM). It caused 28% hemolysis at 100 uM (but 65% at 120 uM) and no hemolysis until 40 uM. AamA
Evidence 7 Activity

Activity

10% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 8 Activity

Activity

50% Cell death
Toxicity
270.2 µg/mL
Cytotoxic
50% Cell death | 270.2 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 9 Activity

Activity

44.3±20.2% Cell death
Toxicity
256 µg/mL
Cytotoxic
44.3±20.2% Cell death | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 10 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 11 Activity

Activity

100% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
100% Hemolysis | 100 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 12 Activity

Activity

44% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
44% Hemolysis | 80 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 13 Activity

Activity

13% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
13% Hemolysis | 60 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 14 Activity

Activity

8% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
8% Hemolysis | 40 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 15 Activity

Activity

0% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
0% Hemolysis | 20 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 16 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.