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Peptide record

TPDB08993

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08993
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RGGRLCYCRGWICFCVGR
Physicochemical Analysis
C90H141N31O20S4
ANDEQHKMPST
RCG
2105.55
9.27
4
0
6
+4
-2.40
0.194
59.44
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
7240
343.85
5
Residue Composition
number
0
A
4
R
0
N
0
D
4
C
0
E
0
Q
4
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
18
C90H141N31O20S4
2105.55
9.27
+4
-2.40
0.194
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
PG-4 inhibited porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells ( Sang et al., 2009 ). PG-4 itself can form amyloid fibrils (amyloid AMPs) ( Gour et al., 2019 .
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
PG-4 inhibited porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells ( Sang et al., 2009 ). PG-4 itself can form amyloid fibrils (amyloid AMPs) ( Gour et al., 2019 .
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
PG-4 inhibited porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells ( Sang et al., 2009 ). PG-4 itself can form amyloid fibrils (amyloid AMPs) ( Gour et al., 2019 .
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
PG-4 inhibited porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells ( Sang et al., 2009 ). PG-4 itself can form amyloid fibrils (amyloid AMPs) ( Gour et al., 2019 .
Evidence 5 Activity

Activity

2% Hemolysis
Toxicity
140 µM
Hemolytic Cytotoxic
2% Hemolysis | 140 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mammalian antimicrobial peptide protegrin-4 self assembles and forms amyloid-like aggregates: Assessment of its functional relevance. | J Pept Sci | 2019
Evidence 6 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Mammalian antimicrobial peptide protegrin-4 self assembles and forms amyloid-like aggregates: Assessment of its functional relevance. | J Pept Sci | 2019
Evidence 7 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.