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Peptide record

TPDB08991

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08991
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPKLFAKITKKNMAHIR
Physicochemical Analysis
C102H170N28O21S1
DCEQGSWYV
K
2156.71
11.80
6
0
9
+5
2.17
-0.078
97.78
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
1
H
2
I
2
L
4
K
1
M
2
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 2 K: 4 M: 1 F: 2 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C102H170N28O21S1
2156.71
11.80
+5
2.17
-0.078
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- bacteria E. coli (MIC 3.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
1.6 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

(MIC 3.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC 1.6 ug/ml), and yeast C. albicans (MIC 1.6 ug/ml). You can rotate, zoom, and view the structure here
Evidence 3 Activity

Activity

MIC
Antibacterial
1.6 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

alled P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC 1.6 ug/ml), and yeast C. albicans (MIC 1.6 ug/ml). You can rotate, zoom, and view the structure here in the PDB . LA turn is lcoated 5-9 an
Evidence 4 Activity

Activity

MIC
Antifungal
3.2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- bacteria E. coli (MIC 3.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 5 Activity

Activity

MIC
Antifungal
1.6 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 3.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC 1.6 ug/ml), and yeast C. albicans (MIC 1.6 ug/ml). You can rotate, zoom, and view the structure here
Evidence 6 Activity

Activity

MIC
Antifungal
1.6 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

alled P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC 1.6 ug/ml), and yeast C. albicans (MIC 1.6 ug/ml). You can rotate, zoom, and view the structure here in the PDB . LA turn is lcoated 5-9 an
Evidence 7 Activity

Activity

MIC
Antiparasitic
3.2 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- bacteria E. coli (MIC 3.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 8 Activity

Activity

MIC
Antiparasitic
1.6 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

(MIC 3.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC 1.6 ug/ml), and yeast C. albicans (MIC 1.6 ug/ml). You can rotate, zoom, and view the structure here
Evidence 9 Activity

Activity

MIC
Antiparasitic
1.6 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

alled P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC 1.6 ug/ml), and yeast C. albicans (MIC 1.6 ug/ml). You can rotate, zoom, and view the structure here in the PDB . LA turn is lcoated 5-9 an
Evidence 10 Activity

Activity

MIC
Antiviral
3.2 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against Gram- bacteria E. coli (MIC 3.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 11 Activity

Activity

MIC
Antiviral
1.6 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

(MIC 3.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC 1.6 ug/ml), and yeast C. albicans (MIC 1.6 ug/ml). You can rotate, zoom, and view the structure here
Evidence 12 Activity

Activity

MIC
Antiviral
1.6 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

alled P. aeruginosa) (MIC 3.2 ug/ml), Gram+ bacteria S. aureus (MIC 1.6 ug/ml), and yeast C. albicans (MIC 1.6 ug/ml). You can rotate, zoom, and view the structure here in the PDB . LA turn is lcoated 5-9 an
Evidence 13 Activity

Activity

5% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
5% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria. | Sci Rep | 2019