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Peptide record

TPDB08989

Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08989
Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 dbAMP DRAMP AntiCP 2.0 iACP-DRLF Antifungipept AVPpred-BWR APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AntiBP3, dbAMP, and other sources, with an available 3D structural model.
Sequence
SAVGRHGRRFGLRKHRKH
Physicochemical Analysis
C92H155N41O20
NDCEQIMPTWY
R
2155.51
13.01
10
0
4
+7
7.28
-1.628
43.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
0
Q
3
G
3
H
0
I
1
L
2
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 3 I: 0 L: 1 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C92H155N41O20
2155.51
13.01
+7
7.28
-1.628
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

Staphylococcus aureus ATCC12600

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Strongly active against S. aureus ATCC12600 (MIC 6 uM) and E. coli ATCC11775 (MIC 3 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Escherichia coli ATCC11775

Source & Reference

dbAMP DRAMP

Other

Strongly active against S. aureus ATCC12600 (MIC 6 uM) and E. coli ATCC11775 (MIC 3 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
6 µM

Target

Staphylococcus aureus ATCC12600

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Strongly active against S. aureus ATCC12600 (MIC 6 uM) and E. coli ATCC11775 (MIC 3 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
3 µM

Target

Escherichia coli ATCC11775

Source & Reference

dbAMP DRAMP Antifungipept

Other

Strongly active against S. aureus ATCC12600 (MIC 6 uM) and E. coli ATCC11775 (MIC 3 uM).
Evidence 5 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Staphylococcus aureus ATCC12600

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Strongly active against S. aureus ATCC12600 (MIC 6 uM) and E. coli ATCC11775 (MIC 3 uM).
Evidence 6 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Escherichia coli ATCC11775

Source & Reference

DRAMP

Other

Strongly active against S. aureus ATCC12600 (MIC 6 uM) and E. coli ATCC11775 (MIC 3 uM).
Evidence 7 Activity

Activity

MIC
Antiviral
6 µM

Target

Staphylococcus aureus ATCC12600

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Strongly active against S. aureus ATCC12600 (MIC 6 uM) and E. coli ATCC11775 (MIC 3 uM).
Evidence 8 Activity

Activity

MIC
Antiviral
3 µM

Target

Escherichia coli ATCC11775

Source & Reference

DRAMP

Other

Strongly active against S. aureus ATCC12600 (MIC 6 uM) and E. coli ATCC11775 (MIC 3 uM).
Evidence 9 Activity

Activity

HC50
Hemolysis
300 µM
[Ref:19539775]HC50>300 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct 154(2):174-178.##Zoolog Sci. 2009 Mar 26(3):220-226.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
>300 µM
Hemolytic Cytotoxic
50% Hemolysis | >300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii. | Comp Biochem Physiol B Biochem Mol Biol | 2009
Evidence 11 Activity

Activity

HC50
Toxicity
300 µM
Hemolytic
Hemolytic_activity: [Ref:19539775]HC50>300 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct 154(2):174-178.##Zoolog Sci. 2009 Mar 26(3):220-226.
Evidence 12 Hemolysis

Activity

300 µM
HC50
[Ref:19539775]HC50>300 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct 154(2):174-178.##Zoolog Sci. 2009 Mar 26(3):220-226.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.