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Peptide record

TPDB08985

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08985
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LVRGCWTKSYPPKPCFVR
Physicochemical Analysis
C99H153N27O22S2
ANDEQHIM
P
2137.59
10.20
4
0
6
+4
0.41
-0.317
53.89
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
7115
332.85
5
Residue Composition
number
0
A
2
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
1
L
2
K
0
M
1
F
3
P
1
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 2 M: 0 F: 1 P: 3 S: 1 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
18
C99H153N27O22S2
2137.59
10.20
+4
0.41
-0.317
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
20 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guille
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

S. lentus

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (M
Evidence 4 Activity

Activity

MIC
Antibacterial
11 µM

Target

C. tropicalis

Source & Reference

dbAMP DRAMP

Other

Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (MIC 75 uM). Antimicrobial activiti
Evidence 5 Activity

Activity

MIC
Antibacterial
6.6 µM

Target

C. guiller-mondii

Source & Reference

dbAMP DRAMP

Other

IC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (MIC 75 uM). Antimicrobial activities of the peptide were reported
Evidence 6 Activity

Activity

MIC
Antibacterial
75 µM

Target

P. nicotianae spores

Source & Reference

dbAMP DRAMP

Other

, M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (MIC 75 uM). Antimicrobial activities of the peptide were reported in Biochemistry 2003 42: 14023-35
Evidence 7 Activity

Activity

MIC
Antifungal
20 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guille
Evidence 8 Activity

Activity

MIC
Antifungal
50 µM

Target

S. lentus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM),
Evidence 9 Activity

Activity

MIC
Antifungal
10 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (M
Evidence 10 Activity

Activity

MIC
Antifungal
11 µM

Target

C. tropicalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (MIC 75 uM). Antimicrobial activiti
Evidence 11 Activity

Activity

MIC
Antifungal
6.6 µM

Target

C. guiller-mondii

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (MIC 75 uM). Antimicrobial activities of the peptide were reported
Evidence 12 Activity

Activity

MIC
Antifungal
75 µM

Target

P. nicotianae spores

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (MIC 75 uM). Antimicrobial activities of the peptide were reported in Biochemistry 2003 42: 14023-35
Evidence 13 Activity

Activity

MIC
Antiparasitic
20 µM

Target

B. megaterium Bm11

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guille
Evidence 14 Activity

Activity

MIC
Antiparasitic
50 µM

Target

S. lentus

Source & Reference

DRAMP

Other

Active against Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM),
Evidence 15 Activity

Activity

MIC
Antiparasitic
10 µM

Target

M. luteus

Source & Reference

DRAMP

Other

Active against Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (M
Evidence 16 Activity

Activity

MIC
Antiparasitic
11 µM

Target

C. tropicalis

Source & Reference

DRAMP

Other

Gram+ B. megaterium Bm11 (MIC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (MIC 75 uM). Antimicrobial activiti
Evidence 17 Activity

Activity

MIC
Antiparasitic
6.6 µM

Target

C. guiller-mondii

Source & Reference

DRAMP

Other

IC 20 uM), S. lentus (MIC 50 uM), M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (MIC 75 uM). Antimicrobial activities of the peptide were reported
Evidence 18 Activity

Activity

MIC
Antiparasitic
75 µM

Target

P. nicotianae spores

Source & Reference

DRAMP

Other

, M. luteus (MIC 10 uM), fungi C. tropicalis (MIC 11 uM), C. guiller-mondii (MIC 6.6 uM), P. nicotianae spores (MIC 75 uM). Antimicrobial activities of the peptide were reported in Biochemistry 2003 42: 14023-35
Evidence 19 Activity

Activity

% Hemolysis
Hemolysis
2.5 %
[Ref:11099505] It has 2.5% hemolytic activity at 100 µM against human red blood

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J. Biol. Chem. 2001 276:10145-10152.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 20 Activity

Activity

85% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
85% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity. | Biochemistry | 2003
Evidence 21 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:11099505] It has 2.5% hemolytic activity at 100 µM against human red blood

Target

erythrocytes

Source & Reference

NA
DRAMP
J. Biol. Chem. 2001 276:10145-10152.
Evidence 22 Hemolysis

Activity

2.5 %
% Hemolysis
[Ref:11099505] It has 2.5% hemolytic activity at 100 µM against human red blood
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J. Biol. Chem. 2001 276:10145-10152.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.