Back to search

Peptide record

TPDB08984

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08984
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIPKFLHSAKKF
Physicochemical Analysis
C115H180N28O20
RNDCEQGMTYV
K
2274.87
11.29
8
0
8
+7
1.63
-0.639
70.56
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
241.77
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
2
L
7
K
0
M
3
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 2 K: 7 M: 0 F: 3 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C115H180N28O20
2274.87
11.29
+7
1.63
-0.639
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 u
Evidence 2 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). moderate activity to cancer cell
Evidence 5 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Streptococcus pyogenes

Source & Reference

dbAMP DRAMP

Other

typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). moderate activity to cancer cells: K-562 (IC50 35 uM), A549
Evidence 6 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). moderate activity to cancer cells: K-562 (IC50 35 uM), A549 (IC50 25 uM), Jurkat (IC50 2
Evidence 7 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 u
Evidence 8 Activity

Activity

MIC
Antifungal
0.78 µM

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM),
Evidence 9 Activity

Activity

MIC
Antifungal
3.12 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
1.56 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). moderate activity to cancer cell
Evidence 11 Activity

Activity

MIC
Antifungal
0.78 µM

Target

Streptococcus pyogenes

Source & Reference

dbAMP DRAMP

Other

typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). moderate activity to cancer cells: K-562 (IC50 35 uM), A549
Evidence 12 Activity

Activity

MIC
Antifungal
3.12 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). moderate activity to cancer cells: K-562 (IC50 35 uM), A549 (IC50 25 uM), Jurkat (IC50 2
Evidence 13 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 u
Evidence 14 Activity

Activity

MIC
Antiparasitic
0.78 µM

Target

S. typhimurium

Source & Reference

DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM),
Evidence 15 Activity

Activity

MIC
Antiparasitic
3.12 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM).
Evidence 16 Activity

Activity

MIC
Antiparasitic
1.56 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). moderate activity to cancer cell
Evidence 17 Activity

Activity

MIC
Antiparasitic
0.78 µM

Target

Streptococcus pyogenes

Source & Reference

DRAMP

Other

typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). moderate activity to cancer cells: K-562 (IC50 35 uM), A549
Evidence 18 Activity

Activity

MIC
Antiparasitic
3.12 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

aeruginosa (MIC 3.12 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). moderate activity to cancer cells: K-562 (IC50 35 uM), A549 (IC50 25 uM), Jurkat (IC50 2
Evidence 19 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells. | Biochim Biophys Acta | 2000
Evidence 20 Activity

Activity

IC50
Toxicity
<100 µM
Cytotoxic
IC50 | <100 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001