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Peptide record

TPDB08983

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08983
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GRFKRFRKKFKKLFKKLS
Physicochemical Analysis
C113H188N34O20
ANDCEQHIMPTWYV
K
2342.95
12.73
10
0
6
+10
3.86
-1.289
43.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
7
K
0
M
4
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 7 M: 0 F: 4 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C113H188N34O20
2342.95
12.73
+10
3.86
-1.289
Evidence Records 33 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcesce
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATC
Evidence 3 Activity

Activity

MIC
Antibacterial
1-4 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

ainst E. coli ATCC 25922 ML-35 or D21 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP DRAMP

Other

MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM
Evidence 5 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Staphylococcus aureus ATCC 25923 Cowan 1 or MRSA

Source & Reference

dbAMP DRAMP

Other

28 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC
Evidence 6 Activity

Activity

MIC
Antibacterial
1-4 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Re
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP

Other

. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Recent MIC values have been merge
Evidence 8 Activity

Activity

MIC
Antibacterial
16 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Recent MIC values have been merged with the previous data.
Evidence 9 Activity

Activity

MIC
Antibacterial
4 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

idis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Recent MIC values have been merged with the previous data. Also inhibited biofilm format
Evidence 10 Activity

Activity

IC50
Antibacterial
8-12 µg/mL

Target

b. brucei

Source & Reference

dbAMP DRAMP

Other

and disrupted preformed biofilms at 8 uM. Also, active against parasite BSF and PCF of T. b. brucei (IC50 8-12 ug/ml), T. b. rhodesiense ViTat 1.1 PCF (IC50 ~30 ug/ml), T. b. gambiense U2 PCF (IC50 ~10 ug/ml
Evidence 11 Activity

Activity

MIC
Antifungal
2-4 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcesce
Evidence 12 Activity

Activity

MIC
Antifungal
4 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATC
Evidence 13 Activity

Activity

MIC
Antifungal
1-4 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst E. coli ATCC 25922 ML-35 or D21 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S
Evidence 14 Activity

Activity

MIC
Antifungal
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM
Evidence 15 Activity

Activity

MIC
Antifungal
2-4 µM

Target

Staphylococcus aureus ATCC 25923 Cowan 1 or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

28 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC
Evidence 16 Activity

Activity

MIC
Antifungal
1-4 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Re
Evidence 17 Activity

Activity

MIC
Antifungal
2 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Recent MIC values have been merge
Evidence 18 Activity

Activity

MIC
Antifungal
16 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Recent MIC values have been merged with the previous data.
Evidence 19 Activity

Activity

MIC
Antifungal
4 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

idis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Recent MIC values have been merged with the previous data. Also inhibited biofilm format
Evidence 20 Activity

Activity

IC50
Antifungal
8-12 µg/mL

Target

b. brucei

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

and disrupted preformed biofilms at 8 uM. Also, active against parasite BSF and PCF of T. b. brucei (IC50 8-12 ug/ml), T. b. rhodesiense ViTat 1.1 PCF (IC50 ~30 ug/ml), T. b. gambiense U2 PCF (IC50 ~10 ug/ml
Evidence 21 Activity

Activity

MIC
Antiparasitic
2-4 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcesce
Evidence 22 Activity

Activity

MIC
Antiparasitic
4 µM

Target

S. typhimurium ATCC 14028

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATC
Evidence 23 Activity

Activity

MIC
Antiparasitic
1-4 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

ainst E. coli ATCC 25922 ML-35 or D21 (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S
Evidence 24 Activity

Activity

MIC
Antiparasitic
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

DRAMP

Other

MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM
Evidence 25 Activity

Activity

MIC
Antiparasitic
2-4 µM

Target

Staphylococcus aureus ATCC 25923 Cowan 1 or MRSA

Source & Reference

DRAMP

Other

28 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1-4 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC
Evidence 26 Activity

Activity

MIC
Antiparasitic
1-4 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

DRAMP

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Re
Evidence 27 Activity

Activity

MIC
Antiparasitic
2 µM

Target

B. megaterium Bm11

Source & Reference

DRAMP

Other

. aureus ATCC 25923 Cowan 1 or MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Recent MIC values have been merge
Evidence 28 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Recent MIC values have been merged with the previous data.
Evidence 29 Activity

Activity

MIC
Antiparasitic
4 µM

Target

C. neoformans

Source & Reference

DRAMP

Other

idis ATCC 12228 (MIC 1-4 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 16 uM), and C. neoformans (MIC 4 uM). Recent MIC values have been merged with the previous data. Also inhibited biofilm format
Evidence 30 Activity

Activity

IC50
Antiparasitic
8-12 µg/mL

Target

b. brucei

Source & Reference

DRAMP

Other

and disrupted preformed biofilms at 8 uM. Also, active against parasite BSF and PCF of T. b. brucei (IC50 8-12 ug/ml), T. b. rhodesiense ViTat 1.1 PCF (IC50 ~30 ug/ml), T. b. gambiense U2 PCF (IC50 ~10 ug/ml
Evidence 31 Activity

Activity

20% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
20% Hemolysis | 64 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Multifunctional Properties of BMAP-18 and Its Aliphatic Analog against Drug-Resistant Bacteria. | Pharmaceuticals (Basel) | 2023
Evidence 32 Activity

Activity

10% Hemolysis
Toxicity
400< µM
Hemolytic Cytotoxic
10% Hemolysis | 400< | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell selectivity, mechanism of action and LPS-neutralizing activity of bovine myeloid antimicrobial peptide-18 (BMAP-18) and its analogs. | Peptides | 2011
Evidence 33 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural analysis and mode of action of BMAP-27, a cathelicidin-derived antimicrobial peptide. | Peptides | 2019