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Peptide record

TPDB08981

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08981
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KNLRRIIRKIIHIIKKYG
Physicochemical Analysis
C105H188N34O21
ADCEQMFPSTWV
I
2262.86
12.16
8
0
8
+7
4.42
-0.372
151.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
65.85
2
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
6
I
1
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 6 L: 1 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
18
C105H188N34O21
2262.86
12.16
+7
4.42
-0.372
Evidence Records 5 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
55 70.2 %
[Ref.11932493]55% hemolytic at 40 µg/mL, 70.2% hemolytic activity at 80 µg/mL against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Protein Eng. 2002 Mar 15(3):225-232.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

70% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
70% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides. | Prot Eng | 2002
Evidence 3 Activity

Activity

9% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
9% Hemolysis | 50 | µg/mL | target cell: Ovine erythrocytes

Target

Ovine erythrocytes

Source & Reference

NA
DBAASP
Evidence 4 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11932493]55% hemolytic at 40 µg/mL, 70.2% hemolytic activity at 80 µg/mL against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Eng. 2002 Mar 15(3):225-232.
Evidence 5 Hemolysis

Activity

55 70.2 %
% Hemolysis
[Ref.11932493]55% hemolytic at 40 µg/mL, 70.2% hemolytic activity at 80 µg/mL against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Protein Eng. 2002 Mar 15(3):225-232.
DRAMP4
PD_Hemolysis