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Peptide record

TPDB08978

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08978
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 AI4AVP AVPpred-BWR DRAVP 2.0 ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFCRCLCRRGVCRCICTR
Physicochemical Analysis
C82H145N33O20S6
ANDEQHKMPSWY
C
2105.62
8.95
5
0
4
+5
0.84
0.350
59.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
17.81
7
Residue Composition
number
0
A
5
R
0
N
0
D
6
C
0
E
0
Q
2
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C82H145N33O20S6
2105.62
8.95
+5
0.84
0.350
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus 502a or MRSA, L. monocytogenes, E. coli ML 35, S. typhimurium, C. albicans 16820, and C. neoformans. Theta-defensins are particularly important for antifungal activity of the granule extracts as alpha-defensins are poorly active (Tongaonkar P et al 2011 J Leuko Biol 89, 283-90). It is also active against HIV-1. RTD-1 inhibits human Papillomavirus (hrHPV, nonenvelope DNA virus) infection through a mechanism involving capsid clustering that inhibits virions from binding to cell surface receptor complexes ( Skeate et al., 2020 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus 502a or MRSA, L. monocytogenes, E. coli ML 35, S. typhimurium, C. albicans 16820, and C. neoformans. Theta-defensins are particularly important for antifungal activity of the granule extracts as alpha-defensins are poorly active (Tongaonkar P et al 2011 J Leuko Biol 89, 283-90). It is also active against HIV-1. RTD-1 inhibits human Papillomavirus (hrHPV, nonenvelope DNA virus) infection through a mechanism involving capsid clustering that inhibits virions from binding to cell surface receptor complexes ( Skeate et al., 2020 ).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against S. aureus 502a or MRSA, L. monocytogenes, E. coli ML 35, S. typhimurium, C. albicans 16820, and C. neoformans. Theta-defensins are particularly important for antifungal activity of the granule extracts as alpha-defensins are poorly active (Tongaonkar P et al 2011 J Leuko Biol 89, 283-90). It is also active against HIV-1. RTD-1 inhibits human Papillomavirus (hrHPV, nonenvelope DNA virus) infection through a mechanism involving capsid clustering that inhibits virions from binding to cell surface receptor complexes ( Skeate et al., 2020 ).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against S. aureus 502a or MRSA, L. monocytogenes, E. coli ML 35, S. typhimurium, C. albicans 16820, and C. neoformans. Theta-defensins are particularly important for antifungal activity of the granule extracts as alpha-defensins are poorly active (Tongaonkar P et al 2011 J Leuko Biol 89, 283-90). It is also active against HIV-1. RTD-1 inhibits human Papillomavirus (hrHPV, nonenvelope DNA virus) infection through a mechanism involving capsid clustering that inhibits virions from binding to cell surface receptor complexes ( Skeate et al., 2020 ).
Evidence 5 Activity

Activity

25% Hemolysis
Toxicity
2350 µM
Hemolytic Cytotoxic
25% Hemolysis | 2350 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. | Biochem Biophys Res Commun | 2000