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Peptide record

TPDB08977

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08977
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 dbACP iACP-DRLF Antifungipept CAFPdb dbAMP 3.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
QCRRLCYKQRCVTYCRGR
Physicochemical Analysis
C93H158N36O24S4
ANDEHIMFPSW
R
2292.74
10.10
6
0
4
+6
3.02
-1.061
37.78
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
3230
140.88
9
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
2
Q
1
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C93H158N36O24S4
2292.74
10.10
+6
3.02
-1.061
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.4-12.5 µM

Target

N. asteroides

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
acidolacrici, S. aureus, S. epidermidis, S. haemolyticus, s. saprophyticus, S. pyogenes, N. asteroides (MIC 0.4-12.5 uM) Gram- A. tumefaciens, E. coli 1106, E. coli D22, E. coli D31, E. coli SBS363, E. carolov
Evidence 2 Activity

Activity

MIC
Antibacterial
0.4-6.2 µM

Target

X. campestris

Source & Reference

dbAMP DRAMP

Other

E. carolovora carolovora, E. cloacae b12, K. pneumoniae, P. aeruginosa, S. thyphinurium, X. campestris (MIC 0.4-6.2 uM) fungi A. brassicola, A. fumigatus, F. culmorum, F. oxysporum, N. crassa, N. haematococca
Evidence 3 Activity

Activity

MIC
Antibacterial
0.4-6.2 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

tococca, T. viridae, T. mentagrophytes yeasts C. albicans, C. tropicalis, C. neoformans, S. cerevisiae (MIC 0.4-6.2 uM), C. glabrata, and B. bassiana (MIC 12.5-25 uM). Also active against P. falciparum.
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

B. bassiana

Source & Reference

dbAMP DRAMP

Other

albicans, C. tropicalis, C. neoformans, S. cerevisiae (MIC 0.4-6.2 uM), C. glabrata, and B. bassiana (MIC 12.5-25 uM). Also active against P. falciparum.
Evidence 5 Activity

Activity

MIC
Antifungal
0.4-12.5 µM

Target

N. asteroides

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
acidolacrici, S. aureus, S. epidermidis, S. haemolyticus, s. saprophyticus, S. pyogenes, N. asteroides (MIC 0.4-12.5 uM) Gram- A. tumefaciens, E. coli 1106, E. coli D22, E. coli D31, E. coli SBS363, E. carolov
Evidence 6 Activity

Activity

MIC
Antifungal
0.4-6.2 µM

Target

X. campestris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

E. carolovora carolovora, E. cloacae b12, K. pneumoniae, P. aeruginosa, S. thyphinurium, X. campestris (MIC 0.4-6.2 uM) fungi A. brassicola, A. fumigatus, F. culmorum, F. oxysporum, N. crassa, N. haematococca
Evidence 7 Activity

Activity

MIC
Antifungal
0.4-6.2 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

tococca, T. viridae, T. mentagrophytes yeasts C. albicans, C. tropicalis, C. neoformans, S. cerevisiae (MIC 0.4-6.2 uM), C. glabrata, and B. bassiana (MIC 12.5-25 uM). Also active against P. falciparum.
Evidence 8 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

B. bassiana

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

albicans, C. tropicalis, C. neoformans, S. cerevisiae (MIC 0.4-6.2 uM), C. glabrata, and B. bassiana (MIC 12.5-25 uM). Also active against P. falciparum.
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.4-12.5 µM

Target

N. asteroides

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
acidolacrici, S. aureus, S. epidermidis, S. haemolyticus, s. saprophyticus, S. pyogenes, N. asteroides (MIC 0.4-12.5 uM) Gram- A. tumefaciens, E. coli 1106, E. coli D22, E. coli D31, E. coli SBS363, E. carolov
Evidence 10 Activity

Activity

MIC
Antiparasitic
0.4-6.2 µM

Target

X. campestris

Source & Reference

dbAMP 3.0 DRAMP

Other

E. carolovora carolovora, E. cloacae b12, K. pneumoniae, P. aeruginosa, S. thyphinurium, X. campestris (MIC 0.4-6.2 uM) fungi A. brassicola, A. fumigatus, F. culmorum, F. oxysporum, N. crassa, N. haematococca
Evidence 11 Activity

Activity

MIC
Antiparasitic
0.4-6.2 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

tococca, T. viridae, T. mentagrophytes yeasts C. albicans, C. tropicalis, C. neoformans, S. cerevisiae (MIC 0.4-6.2 uM), C. glabrata, and B. bassiana (MIC 12.5-25 uM). Also active against P. falciparum.
Evidence 12 Activity

Activity

MIC
Antiparasitic
12.5-25 µM

Target

B. bassiana

Source & Reference

dbAMP 3.0 DRAMP

Other

albicans, C. tropicalis, C. neoformans, S. cerevisiae (MIC 0.4-6.2 uM), C. glabrata, and B. bassiana (MIC 12.5-25 uM). Also active against P. falciparum.
Evidence 13 Activity

Activity

% Hemolysis
Hemolysis
16 %
[Ref.10942757] It exhibits 16% hemolysis at 1 µM and 100 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Biol Chem. 2000 Oct 27 275(43):33464-70.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

35% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
35% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and properties of cyclic gomesin and analogues. | J Pept Sci | 2012
Evidence 15 Activity

Activity

% Hemolysis
Toxicity
16 %
Hemolytic
Hemolytic_activity: [Ref.10942757] It exhibits 16% hemolysis at 1 µM and 100 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2000 Oct 27 275(43):33464-70.
Evidence 16 Hemolysis

Activity

16 %
% Hemolysis
[Ref.10942757] It exhibits 16% hemolysis at 1 µM and 100 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Biol Chem. 2000 Oct 27 275(43):33464-70.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.