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Peptide record

TPDB08976

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08976
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KNLRRITRKIIHIIKKYG
Physicochemical Analysis
C103H184N34O22
ADCEQMFPSWV
I
2250.81
12.16
8
0
7
+7
4.87
-0.661
130.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
66.20
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
5
I
1
L
4
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 5 L: 1 K: 4 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
18
C103H184N34O22
2250.81
12.16
+7
4.87
-0.661
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.26-27.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against 9 strains P. aeruginosa (MIC 0.26-27.8 ug/ml), 5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), an
Evidence 2 Activity

Activity

MIC
Antibacterial
0.32-1.75 µg/mL

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP DRAMP

Other

active against 9 strains P. aeruginosa (MIC 0.26-27.8 ug/ml), 5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), and S. aureus 930918 (MIC 3.3 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
2.4 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

ains P. aeruginosa (MIC 0.26-27.8 ug/ml), 5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), and S. aureus 930918 (MIC 3.3 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
3.3 µg/mL

Target

Staphylococcus aureus 930918

Source & Reference

dbAMP DRAMP

Other

5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), and S. aureus 930918 (MIC 3.3 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
0.26-27.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against 9 strains P. aeruginosa (MIC 0.26-27.8 ug/ml), 5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), an
Evidence 6 Activity

Activity

MIC
Antifungal
0.32-1.75 µg/mL

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP DRAMP

Other

active against 9 strains P. aeruginosa (MIC 0.26-27.8 ug/ml), 5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), and S. aureus 930918 (MIC 3.3 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
2.4 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

ains P. aeruginosa (MIC 0.26-27.8 ug/ml), 5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), and S. aureus 930918 (MIC 3.3 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
3.3 µg/mL

Target

Staphylococcus aureus 930918

Source & Reference

dbAMP DRAMP

Other

5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), and S. aureus 930918 (MIC 3.3 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.26-27.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against 9 strains P. aeruginosa (MIC 0.26-27.8 ug/ml), 5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), an
Evidence 10 Activity

Activity

MIC
Antiparasitic
0.32-1.75 µg/mL

Target

Stenotrophomonas maltophilia

Source & Reference

DRAMP

Other

active against 9 strains P. aeruginosa (MIC 0.26-27.8 ug/ml), 5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), and S. aureus 930918 (MIC 3.3 ug/ml).
Evidence 11 Activity

Activity

MIC
Antiparasitic
2.4 µg/mL

Target

L. monocytogenes EGD

Source & Reference

DRAMP

Other

ains P. aeruginosa (MIC 0.26-27.8 ug/ml), 5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), and S. aureus 930918 (MIC 3.3 ug/ml).
Evidence 12 Activity

Activity

MIC
Antiparasitic
3.3 µg/mL

Target

Staphylococcus aureus 930918

Source & Reference

DRAMP

Other

5 strains S. maltophilia (MIC 0.32-1.75 ug/ml), L. monocytogenes EGD (MIC 2.4 ug/ml), and S. aureus 930918 (MIC 3.3 ug/ml).
Evidence 13 Activity

Activity

% Hemolysis
Hemolysis
3 10 %
[Ref.11932493]3% hemolytic at 40 µg/mL, 10% hemolytic activity at 80 µg/mL against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Protein Eng. 2002 Mar 15(3):225-232.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

12% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
12% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011
Evidence 15 Activity

Activity

10% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides. | Prot Eng | 2002
Evidence 16 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11932493]3% hemolytic at 40 µg/mL, 10% hemolytic activity at 80 µg/mL against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Eng. 2002 Mar 15(3):225-232.
Evidence 17 Hemolysis

Activity

3 10 %
% Hemolysis
[Ref.11932493]3% hemolytic at 40 µg/mL, 10% hemolytic activity at 80 µg/mL against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Protein Eng. 2002 Mar 15(3):225-232.
DRAMP4
PD_Hemolysis