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Peptide record

TPDB08975

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08975
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF i2APP ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KNLRRIIRKGIHIIKKYG
Physicochemical Analysis
C101H180N34O21
ADCEQMFPSTWV
I
2206.76
12.16
8
0
7
+7
4.74
-0.644
130.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
67.52
2
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
0
Q
2
G
1
H
5
I
1
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 5 L: 1 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
18
C101H180N34O21
2206.76
12.16
+7
4.74
-0.644
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.11-12.7 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against 9 strains P. aeruginosa (MIC 0.11-12.7 ug/ml), 5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and
Evidence 2 Activity

Activity

MIC
Antibacterial
0.29-3.6 µg/mL

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP DRAMP

Other

active against 9 strains P. aeruginosa (MIC 0.11-12.7 ug/ml), 5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and S. aureus 930918 (MIC 4.6 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
1.4 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

rains P. aeruginosa (MIC 0.11-12.7 ug/ml), 5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and S. aureus 930918 (MIC 4.6 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
4.6 µg/mL

Target

Staphylococcus aureus 930918

Source & Reference

dbAMP DRAMP

Other

5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and S. aureus 930918 (MIC 4.6 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
0.11-12.7 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against 9 strains P. aeruginosa (MIC 0.11-12.7 ug/ml), 5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and
Evidence 6 Activity

Activity

MIC
Antifungal
0.29-3.6 µg/mL

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP DRAMP

Other

active against 9 strains P. aeruginosa (MIC 0.11-12.7 ug/ml), 5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and S. aureus 930918 (MIC 4.6 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
1.4 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

rains P. aeruginosa (MIC 0.11-12.7 ug/ml), 5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and S. aureus 930918 (MIC 4.6 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
4.6 µg/mL

Target

Staphylococcus aureus 930918

Source & Reference

dbAMP DRAMP

Other

5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and S. aureus 930918 (MIC 4.6 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.11-12.7 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against 9 strains P. aeruginosa (MIC 0.11-12.7 ug/ml), 5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and
Evidence 10 Activity

Activity

MIC
Antiparasitic
0.29-3.6 µg/mL

Target

Stenotrophomonas maltophilia

Source & Reference

DRAMP

Other

active against 9 strains P. aeruginosa (MIC 0.11-12.7 ug/ml), 5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and S. aureus 930918 (MIC 4.6 ug/ml).
Evidence 11 Activity

Activity

MIC
Antiparasitic
1.4 µg/mL

Target

L. monocytogenes EGD

Source & Reference

DRAMP

Other

rains P. aeruginosa (MIC 0.11-12.7 ug/ml), 5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and S. aureus 930918 (MIC 4.6 ug/ml).
Evidence 12 Activity

Activity

MIC
Antiparasitic
4.6 µg/mL

Target

Staphylococcus aureus 930918

Source & Reference

DRAMP

Other

5 strains S. maltophilia (MIC 0.29-3.6 ug/ml), L. monocytogenes EGD (MIC 1.4 ug/ml), and S. aureus 930918 (MIC 4.6 ug/ml).
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
>>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >>100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011
Evidence 14 Activity

Activity

3% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 15 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11932493]1.8% hemolytic at 40 µg/mL, 2.5% hemolytic activity at 80 µg/mL against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Eng. 2002 Mar 15(3):225-232.